对来自不同类型肿瘤的培养淋巴细胞中的双微体染色体进行的一项研究。
A search for double minute chromosomes in cultured lymphocytes from different types of tumors.
作者信息
Scappaticci S, Fossati G S, Valenti L, Scabini M, Tateo S, Nastasi G, Spina M P, Capra E
机构信息
Biologia Generale e Genetica Medica, Università di Pavia, Italy.
出版信息
Cancer Genet Cytogenet. 1995 Jul 1;82(1):50-3. doi: 10.1016/0165-4608(94)00288-m.
Double minutes are considered the products of DNA amplification and are rare in normal human cells. They have been observed in cultured lymphocytes in selected samples of human populations as one of the characteristics of the so-called rogue cells. We scored 9500 metaphases of cultured lymphocytes from 65 subjects with a variety of heredity and sporadic tumors and from 30 healthy subjects. The 15 cells with double minutes were found in subjects with multiple endocrine neoplasia type 1 (14 cases) and with familial adenomatous polyposis (1 case). Only one rogue cell was found among the 15 cells with double minutes.
双微体被认为是DNA扩增的产物，在正常人类细胞中很少见。在特定人群样本的培养淋巴细胞中，双微体作为所谓流氓细胞的特征之一被观察到。我们对来自65名患有各种遗传性和散发性肿瘤的受试者以及30名健康受试者的培养淋巴细胞的9500个中期相进行了评分。在1型多发性内分泌肿瘤患者（14例）和家族性腺瘤性息肉病患者（1例）中发现了15个含有双微体的细胞。在这15个含有双微体的细胞中仅发现1个流氓细胞。
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