Ohkoshi N, Ishii A, Shoji S
Department of Neurology, University of Tsukuba, Japan.
Eur Neurol. 1995;35(3):156-61. doi: 10.1159/000117113.
We investigated the clinical usefulness of N-isopropyl-p-[123I]iodoamphetamine single photon emission computed tomography (SPECT) for diagnosis of spinocerebellar degeneration. The uptake in the cerebellar hemispheres and vermis was decreased in sporadic cerebelloolivary atrophy (Holmes, n = 9) and sporadic olivopontocerebellar atrophy (OPCA, n = 6). The uptake in the pons was decreased in OPCA. The decrease of the uptake in the cerebellum and the pons was associated with clinical severity in OPCA. Our results show that semiquantitative SPECT analysis differentiates between the Holmes type and OPCA.
我们研究了N-异丙基-p-[123I]碘安非他明单光子发射计算机断层扫描（SPECT）在诊断脊髓小脑变性中的临床应用价值。在散发性小脑橄榄萎缩（霍姆斯型，n = 9）和散发性橄榄脑桥小脑萎缩（OPCA，n = 6）中，小脑半球和蚓部的摄取减少。在OPCA中脑桥的摄取减少。小脑和脑桥摄取的减少与OPCA的临床严重程度相关。我们的结果表明，半定量SPECT分析可区分霍姆斯型和OPCA。
