Khvatova E M, Rubanova N A, Prudchenko I A, Mikhaleva I I
Nizhnii Novgorod Medical Academy, Russian Federation.
FEBS Lett. 1995 Jul 17;368(2):367-9. doi: 10.1016/0014-5793(95)00661-r.
Metabolic effects of delta-sleep inducing peptide (DSIP) under hypoxia stress were investigated in rats subjected to short-term hypoxic conditions (about 0.26 Bar). It was found that DSIP partially restricted stress-induced changes in activity of mitochondrial monoamine oxidase type A (MAO-A) and serotonin level in rat brain. A number of DSIP analogues was tested and among them there were some compounds with enhanced ability to counteract hypoxia induced changes in MAO-A activity and serotonin content in comparison with native neuropeptide.
在短期低氧条件（约0.26巴）下的大鼠中研究了δ-睡眠诱导肽（DSIP）在低氧应激下的代谢作用。发现DSIP部分限制了应激诱导的大鼠脑中线粒体A型单胺氧化酶（MAO-A）活性和血清素水平的变化。测试了许多DSIP类似物，其中有一些化合物与天然神经肽相比，具有更强的抵消低氧诱导的MAO-A活性和血清素含量变化的能力。
