Ito H, Yoshimura T, Furuya T, Tsujino A, Suenaga A, Nagataki S
First Department of Internal Medicine, Nagasaki University.
Fukuoka Igaku Zasshi. 1995 May;86(5):267-72.
The effects of polychlorinated biphenyls (PCB) on regeneration of the peripheral nerves were investigated in rats. The sciatic nerves were crushed at the mid-thigh level on the last day of 32 days of oral administration of PCB. The sciatic nerves were biopsied from the crushed regions at 1, 2, 4, 8 and 12 weeks after crushing. Myelin thickness on the axon diameter was smaller in the PCB administered group than in the control group. There was no difference between the experimental group and the control group in the density of regenerating fibers and distribution of fiber diameters in unmyelinated fibers. After 12 weeks the number of large diameter myelinated fiber densities was lower in the experimental group than in the control group. These results indicate that PCB may affect the remyelination of the regenerating nerve.
研究了多氯联苯（PCB）对大鼠周围神经再生的影响。在口服PCB 32天的最后一天，将大鼠的坐骨神经在大腿中部水平处挤压。在挤压后1、2、4、8和12周，从挤压部位取坐骨神经进行活检。与对照组相比，PCB给药组轴突直径上的髓鞘厚度更小。在再生纤维密度和无髓纤维的纤维直径分布方面，实验组和对照组之间没有差异。12周后，实验组大直径有髓纤维密度低于对照组。这些结果表明，PCB可能会影响再生神经的髓鞘再生。
