多药耐药性——生物能量学中一个引人入胜且与临床相关的问题。 - Suppr

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超能文献

Multidrug resistance--a fascinating, clinically relevant problem in bioenergetics.

作者信息

Pedersen P L

机构信息

Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205-2185, USA.

出版信息

J Bioenerg Biomembr. 1995 Feb;27(1):3-5. doi: 10.1007/BF02110324.

DOI:10.1007/BF02110324

PMID:7629048

Abstract

摘要

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Cloning and functional analysis of an extrachromosomally amplified multidrug resistance-like gene in Leishmania enriettii.恩氏利什曼原虫中一个染色体外扩增的多药耐药样基因的克隆与功能分析。

Mol Biochem Parasitol. 1993 Aug;60(2):195-208. doi: 10.1016/0166-6851(93)90131-g.

Multidrug resistance pumps in bacteria: variations on a theme.细菌中的多药耐药泵：同一主题的变体

Trends Biochem Sci. 1994 Mar;19(3):119-23. doi: 10.1016/0968-0004(94)90204-6.

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease.小鼠mdr2 P-糖蛋白基因的纯合缺失导致胆汁中完全没有磷脂，并引发肝脏疾病。

Cell. 1993 Nov 5;75(3):451-62. doi: 10.1016/0092-8674(93)90380-9.

Molecular characterization of the ldmdr1 multidrug resistance gene from Leishmania donovani.来自杜氏利什曼原虫的ldmdr1多药耐药基因的分子特征分析

Mol Biochem Parasitol. 1993 Jul;60(1):53-64. doi: 10.1016/0166-6851(93)90028-v.

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Cancer Res. 1993 Feb 15;53(4):747-54.

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J Biol Chem. 1994 Nov 25;269(47):29998-30004.

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Cancer Res. 1981 May;41(5):1967-72.

Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement.维拉帕米对多药耐药K562细胞的质膜进行ATP依赖的高亲和力长春新碱结合的竞争性抑制，且不涉及钙离子。

Cancer Res. 1989 Mar 15;49(6):1452-5.

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