Pitkänen A, Stefanacci L, Farb C R, Go G G, LeDoux J E, Amaral D G
Department of Neurology, University of Kuopio, Finland.
J Comp Neurol. 1995 May 29;356(2):288-310. doi: 10.1002/cne.903560211.
The amygdaloid complex receives sensory information from a variety of sources. A widely held view is that the amygdaloid complex utilizes this information to orchestrate appropriate species-specific behaviors to ongoing experiences. Relatively little is known, however, about the circuitry through which information is processed within the amygdaloid complex. The lateral nucleus is the major recipient of extrinsic sensory information and is the origin of many intra-amygdaloid projections. In this study, we reinvestigated the organization of intra-amygdaloid projections originating from the lateral nucleus using the anterograde tracer Phaseolus vulgaris leucoagglutinin (PHA-L). The lateral nucleus has highly organized intranuclear connections. Dense projections interconnect rostral and caudal levels of the lateral and the medial divisions of the nucleus, and the lateral and medial divisions of the lateral nucleus are also interconnected. The major extranuclear projections of the lateral nucleus are (in descending order of magnitude) to the accessory basal nucleus, the basal nucleus, the periamygdaloid cortex, the dorsal portion of the central division of the medial nucleus, the posterior cortical nucleus, the capsular division of the central nucleus, and the lateral division of the amygdalohippocampal area. The pattern of extranuclear projections varied depending on the rostrocaudal or mediolateral location of the injection site within the lateral nucleus. These findings indicate that intra-amygdaloid projections originating in the lateral nucleus are both more widespread and more topographically organized than was previously appreciated.
杏仁复合体从多种来源接收感觉信息。一种广泛持有的观点是，杏仁复合体利用这些信息来协调针对当前经历的适当物种特异性行为。然而，关于杏仁复合体内信息处理所通过的神经回路，我们所知相对较少。外侧核是外部感觉信息的主要接收者，也是许多杏仁体内投射的起源。在本研究中，我们使用顺行示踪剂菜豆白细胞凝集素（PHA-L）重新研究了源自外侧核的杏仁体内投射的组织。外侧核具有高度组织化的核内连接。密集的投射将核的外侧和内侧部分的吻侧和尾侧水平相互连接，并且外侧核的外侧和内侧部分也相互连接。外侧核的主要核外投射（按大小降序排列）是到副基底核、基底核、杏仁周皮质、内侧核中央部的背侧部分、后皮质核、中央核的被膜部以及杏仁海马区的外侧部。核外投射的模式因外侧核内注射部位的前后或内外侧位置而异。这些发现表明，源自外侧核的杏仁体内投射比以前所认识到的更为广泛且在拓扑学上更具组织性。
