Michel M C, Rascher W
Department of Medicine, University of Essen, Germany.
J Hypertens. 1995 Apr;13(4):385-95.
To evaluate whether neuropeptide Y (NPY) is likely to be relevant as a regulator of cardiovascular function in general and of blood pressure control in arterial hypertension in particular, based on a literature survey.
NPY is a putative cotransmitter of many central and peripheral sympathetic neurons. It and its receptors are present in brain areas and peripheral tissues involved in cardiovascular regulation, and administration of exogenous NPY to these sites can elicit functional cardiovascular responses by acting on specific pre- and postsynaptic receptors. Moreover, NPY may act as a growth factor for the development of vascular and cardiac hypertrophy. The release of NPY and postsynaptic vasoconstriction responses to NPY may be enhanced in hypertension, whereas presynaptic inhibitory responses may be attenuated. Some of these alterations may precede the development of blood pressure elevations in the spontaneously hypertensive rat model of genetic hypertension.
NPY might be an important physiological and pathophysiological modulator of cardiovascular function, but further studies using specific high-affinity antagonists are required.
基于文献调查，评估神经肽Y（NPY）是否可能作为心血管功能的一般调节因子，特别是作为动脉高血压血压控制的调节因子。
NPY是许多中枢和外周交感神经元的一种假定的共同递质。它及其受体存在于参与心血管调节的脑区和外周组织中，向这些部位施用外源性NPY可通过作用于特定的突触前和突触后受体引发功能性心血管反应。此外，NPY可能作为血管和心脏肥大发展的生长因子。在高血压中，NPY的释放以及对NPY的突触后血管收缩反应可能增强，而突触前抑制反应可能减弱。在遗传性高血压的自发性高血压大鼠模型中，其中一些改变可能先于血压升高的发生。
NPY可能是心血管功能的重要生理和病理生理调节因子，但需要使用特异性高亲和力拮抗剂进行进一步研究。
