血清肿瘤标志物癌胚抗原（CEA）、糖类抗原15.3（CA 15.3）和糖类抗原27.29（CA 27.29）作为乳腺癌患者诊断参数的研究。

Study of serum tumor markers CEA, CA 15.3 and CA 27.29 as diagnostic parameters in patients with breast carcinoma.

作者信息

Rodríguez de Paterna L, Arnaiz F, Estenoz J, Ortuño B, Lanzós E

机构信息

Department of Radiotherapeutical Oncology, Hospital Universitario Doce de Octubre de Madrid, Spain.

出版信息

Int J Biol Markers. 1995 Jan-Mar;10(1):24-9. doi: 10.1177/172460089501000105.

DOI:10.1177/172460089501000105

PMID:7629423

Abstract

Serum levels of CEA, CA 15.3 and CA 27.29 were measured during the follow-up of 499 breast cancer patients. Studies included three different groups of women: 82 blood donors free of disease, 42 patients with non-malignant breast diseases and 499 breast cancer patients. After the determination of cut-off values, serum levels of tumor markers did not show significant elevations in benign breast diseases. On the basis of our results CA 15.3 (sensitivity = 57%; accuracy = 87%) was the most effective marker, CA 27.29 (sensitivity = 62%; accuracy = 83%) was the most sensitive and CEA (sensitivity = 45%; accuracy = 81%) was the least sensitive and effective marker. The combined use of markers was evaluated by step-wise logistic regression analysis. The regression coefficients showed that CA 15.3 (coeff. = 2.97) and CA 27.29 (coeff. = 1.46) were suitable for the detection of possible metastases during follow-up. Finally, we studied the relationship between pT, pN, pM and circulating levels of CA 15.3 and CA 27.29.

摘要

在499例乳腺癌患者的随访过程中测定了癌胚抗原（CEA）、糖类抗原15.3（CA 15.3）和糖类抗原27.29（CA 27.29）的血清水平。研究纳入了三组不同的女性：82例无疾病的献血者、42例患有非恶性乳腺疾病的患者和499例乳腺癌患者。在确定临界值后，肿瘤标志物的血清水平在良性乳腺疾病中未显示出显著升高。根据我们的结果，CA 15.3（敏感性=57%；准确性=87%）是最有效的标志物，CA 27.29（敏感性=62%；准确性=83%）是最敏感的，而CEA（敏感性=45%；准确性=81%）是最不敏感和有效的标志物。通过逐步逻辑回归分析评估标志物的联合使用。回归系数表明，CA 15.3（系数=2.97）和CA 27.29（系数=1.46）适用于随访期间检测可能的转移。最后，我们研究了pT、pN、pM与CA 15.3和CA 27.29循环水平之间的关系。