Rodríguez de Paterna L, Arnaiz F, Estenoz J, Ortuño B, Lanzós E
Department of Radiotherapeutical Oncology, Hospital Universitario Doce de Octubre de Madrid, Spain.
Int J Biol Markers. 1995 Jan-Mar;10(1):24-9. doi: 10.1177/172460089501000105.
Serum levels of CEA, CA 15.3 and CA 27.29 were measured during the follow-up of 499 breast cancer patients. Studies included three different groups of women: 82 blood donors free of disease, 42 patients with non-malignant breast diseases and 499 breast cancer patients. After the determination of cut-off values, serum levels of tumor markers did not show significant elevations in benign breast diseases. On the basis of our results CA 15.3 (sensitivity = 57%; accuracy = 87%) was the most effective marker, CA 27.29 (sensitivity = 62%; accuracy = 83%) was the most sensitive and CEA (sensitivity = 45%; accuracy = 81%) was the least sensitive and effective marker. The combined use of markers was evaluated by step-wise logistic regression analysis. The regression coefficients showed that CA 15.3 (coeff. = 2.97) and CA 27.29 (coeff. = 1.46) were suitable for the detection of possible metastases during follow-up. Finally, we studied the relationship between pT, pN, pM and circulating levels of CA 15.3 and CA 27.29.
在499例乳腺癌患者的随访过程中测定了癌胚抗原（CEA）、糖类抗原15.3（CA 15.3）和糖类抗原27.29（CA 27.29）的血清水平。研究纳入了三组不同的女性：82例无疾病的献血者、42例患有非恶性乳腺疾病的患者和499例乳腺癌患者。在确定临界值后，肿瘤标志物的血清水平在良性乳腺疾病中未显示出显著升高。根据我们的结果，CA 15.3（敏感性=57%；准确性=87%）是最有效的标志物，CA 27.29（敏感性=62%；准确性=83%）是最敏感的，而CEA（敏感性=45%；准确性=81%）是最不敏感和有效的标志物。通过逐步逻辑回归分析评估标志物的联合使用。回归系数表明，CA 15.3（系数=2.97）和CA 27.29（系数=1.46）适用于随访期间检测可能的转移。最后，我们研究了pT、pN、pM与CA 15.3和CA 27.29循环水平之间的关系。
