1985 - 1992年英格兰北部的肢体减少缺陷
Limb reduction defects in the northern region of England 1985-92.
作者信息
Wright M J, Newell J N, Charlton M E, Hey E N, Donaldson L J, Burn J
机构信息
Department of Human Genetics, University of Newcastle upon Tyne.
出版信息
J Epidemiol Community Health. 1995 Jun;49(3):305-8. doi: 10.1136/jech.49.3.305.
STUDY OBJECTIVE
To test the hypothesis that children born to mothers living near the sea are at increased risk of limb reduction defects.
DESIGN
Descriptive data analysis.
SETTING
The northern health region of England.
PATIENTS
All children born between 1 January 1985 and 31 December 1992 in the northern region of England with isolated limb reduction defects.
MAIN RESULTS
The birth prevalence of isolated limb reduction defects was not affected by the distance the mother lived from the sea. There was some evidence of space-time clustering, but there was no evidence of statistically significant variation in the occurrence of the condition with sex, time of birth (monthly or yearly), or county of birth.
CONCLUSIONS
There is no evidence that children born to mothers living near the sea are at increased risk of limb reduction defects.
研究目的
检验居住在海边的母亲所生子女肢体减少缺陷风险增加这一假设。
设计
描述性数据分析。
地点
英格兰北部健康地区。
研究对象
1985年1月1日至1992年12月31日在英格兰北部地区出生的所有患有孤立性肢体减少缺陷的儿童。
主要结果
孤立性肢体减少缺陷的出生患病率不受母亲居住地点与海的距离影响。有一些时空聚集的证据，但没有证据表明该疾病的发生在性别、出生时间（按月或按年）或出生郡县方面存在统计学上的显著差异。
结论
没有证据表明居住在海边的母亲所生子女患肢体减少缺陷的风险增加。
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