单个T细胞受体对多个肽核心的识别。
Recognition of multiple peptide cores by a single T cell receptor.
作者信息
Nanda N K, Arzoo K K, Geysen H M, Sette A, Sercarz E E
机构信息
Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024-1489, USA.
出版信息
J Exp Med. 1995 Aug 1;182(2):531-9. doi: 10.1084/jem.182.2.531.
Abstract
We present evidence that a single T cell clone can recognize at least five different overlapping peptides, each with its distinct core structure, in the context of the same major histocompatibility complex (MHC) molecule. Distinct core residues are crucial for triggering the T cell receptor (TCR) in each case. These results suggest that the TCR (a) has multiple sets of contact residues for alternative peptide-MHC ligands, the binding to any one of which can trigger the cell; and/or (b) is able to attach to the peptide-MHC complex in more than one orientation. In this sense, the TCR is a multisubsite structure capable of being stimulated by a variety of peptide ligands associated with the same MHC molecules.
摘要
我们提供的证据表明，在同一主要组织相容性复合体（MHC）分子的背景下，单个T细胞克隆能够识别至少五种不同的重叠肽段，每个肽段都有其独特的核心结构。在每种情况下，不同的核心残基对于触发T细胞受体（TCR）至关重要。这些结果表明，TCR（a）具有多组与替代性肽-MHC配体结合的接触残基，与其中任何一个结合都能触发细胞；和/或（b）能够以不止一种取向附着于肽-MHC复合物。从这个意义上说，TCR是一种多亚位点结构，能够被与同一MHC分子相关的多种肽配体刺激。
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