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T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro.人肥大细胞体外分化过程中2型辅助性T细胞细胞因子介导的促有丝分裂反应及CCR3表达
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本文引用的文献

1
Strain-specific and tissue-specific expression of mouse mast cell secretory granule proteases.小鼠肥大细胞分泌颗粒蛋白酶的菌株特异性和组织特异性表达。
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):128-32. doi: 10.1073/pnas.91.1.128.
2
Mast cells lacking the high affinity immunoglobulin E receptor are deficient in Fc epsilon RI gamma messenger RNA.缺乏高亲和力免疫球蛋白E受体的肥大细胞中FcεRIγ信使核糖核酸不足。
J Exp Med. 1995 Aug 1;182(2):567-74. doi: 10.1084/jem.182.2.567.
3
Biochemical analysis of glucocorticoid-induced inhibition of IgE-mediated histamine release from mouse mast cells.糖皮质激素诱导抑制小鼠肥大细胞中IgE介导的组胺释放的生化分析。
J Immunol. 1982 Sep;129(3):1212-8.
4
The receptor with high affinity for immunoglobulin E.对免疫球蛋白E具有高亲和力的受体。
Annu Rev Immunol. 1986;4:419-70. doi: 10.1146/annurev.iy.04.040186.002223.
5
Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S).一种对白细胞介素-4和白细胞介素-2高度敏感的T细胞系（CT.4R）及其该细胞系的白细胞介素-2低反应性突变体（CT.4S）的衍生。
J Immunol. 1989 Feb 1;142(3):800-7.
6
Origins and properties of hematopoietic growth factor-dependent cell lines.造血生长因子依赖性细胞系的起源与特性
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7
The mouse W/c-kit locus.小鼠W/c-kit基因座。
Ciba Found Symp. 1990;148:158-66; discussion 166-72.
8
Characterization of the target cell receptor for IgE. II. Polyacrylamide gel analysis of the surface IgE receptor from normal rat mast cells and from rat basophilic leukemia cells.IgE靶细胞受体的特性。II. 正常大鼠肥大细胞和大鼠嗜碱性白血病细胞表面IgE受体的聚丙烯酰胺凝胶分析。
J Immunol. 1976 Feb;116(2):319-26.

小鼠骨髓细胞培养物中FcεRI阴性肥大细胞的鉴定。单克隆抗-p161抗体的应用。

Identification of Fc epsilon RIneg mast cells in mouse bone marrow cell cultures. Use of a monoclonal anti-p161 antibody.

作者信息

Kinzer C A, Keegan A D, Paul W E

机构信息

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1892, USA.

出版信息

J Exp Med. 1995 Aug 1;182(2):575-9. doi: 10.1084/jem.182.2.575.

DOI:10.1084/jem.182.2.575
PMID:7629514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2192123/
Abstract

A monoclonal hamster antibody (K-1) specific for a 161-kD mast cell surface glycoprotein was derived. p161 is expressed on normal and cultured mast cells and on some macrophages, but not on basophils or other hematopoietic cells. A population of Fc epsilon Rneg cells expressing p161 was found in short term cultures of bone marrow cells grown in interleukin (IL)-3. These cells were purified and propagated for extended periods in IL-3. They express c-kit and Fc gamma RII/III, contain alcian blue-positive granules and histamine, and secrete IL-3 in response to ionomycin treatment. Their morphology is consistent with that of mast cells. We propose that they represent Fc epsilon RIneg mast cells that can be detected and purified because of their p161 expression.

摘要

获得了一种针对161-kD肥大细胞表面糖蛋白的单克隆仓鼠抗体（K-1）。p161在正常和培养的肥大细胞以及一些巨噬细胞上表达，但在嗜碱性粒细胞或其他造血细胞上不表达。在白细胞介素（IL）-3中生长的骨髓细胞短期培养物中发现了一群表达p161的FcεRneg细胞。这些细胞被纯化并在IL-3中长时间传代培养。它们表达c-kit和FcγRII/III，含有阿尔辛蓝阳性颗粒和组胺，并在离子霉素处理后分泌IL-3。它们的形态与肥大细胞一致。我们认为它们代表了由于表达p161而可被检测和纯化的FcεRIneg肥大细胞。