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1
Mast cells lacking the high affinity immunoglobulin E receptor are deficient in Fc epsilon RI gamma messenger RNA.缺乏高亲和力免疫球蛋白E受体的肥大细胞中FcεRIγ信使核糖核酸不足。
J Exp Med. 1995 Aug 1;182(2):567-74. doi: 10.1084/jem.182.2.567.
2
Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions.表达人类高亲和力免疫球蛋白（Ig）E受体α链的转基因小鼠在肥大细胞脱颗粒和过敏反应中对人类IgE产生反应。
J Exp Med. 1996 Jan 1;183(1):49-56. doi: 10.1084/jem.183.1.49.
3
Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors.小鼠低亲和力IgG受体对高亲和力IgE受体介导的肥大细胞活化的调节
J Clin Invest. 1995 Feb;95(2):577-85. doi: 10.1172/JCI117701.
4
T cell receptor-independent CD2 signal transduction in FcR+ cells.FcR⁺细胞中不依赖T细胞受体的CD2信号转导
J Exp Med. 1991 Apr 1;173(4):859-68. doi: 10.1084/jem.173.4.859.
5
Murine KIT+ lineage- bone marrow progenitors express Fc gamma-RII but do not express Fc epsilon-RI until mast cell granule formation.小鼠KIT+谱系阴性骨髓祖细胞表达Fcγ-RII，但在肥大细胞颗粒形成之前不表达Fcε-RI。
J Immunol. 1995 Jan 1;154(1):355-62.
6
Regulation of mouse mast cell surface Fc epsilon RI expression by dexamethasone.地塞米松对小鼠肥大细胞表面FcεRI表达的调控
Int Immunol. 2001 Jul;13(7):843-51. doi: 10.1093/intimm/13.7.843.
7
Characterization of Fc gamma receptors on rat mucosal mast cells using a mutant Fc epsilon RI-deficient rat basophilic leukemia line.使用FcεRI缺陷型大鼠嗜碱性白血病细胞系对大鼠黏膜肥大细胞上的Fcγ受体进行表征。
Eur J Immunol. 1995 Oct;25(10):2948-55. doi: 10.1002/eji.1830251035.
8
CD3 zeta subunit can substitute for the gamma subunit of Fc epsilon receptor type I in assembly and functional expression of the high-affinity IgE receptor: evidence for interreceptor complementation.CD3 ζ 亚基可在高亲和力 IgE 受体的组装和功能表达中替代 I 型 Fcε 受体的 γ 亚基：受体间互补的证据。
Proc Natl Acad Sci U S A. 1990 Sep;87(18):7015-9. doi: 10.1073/pnas.87.18.7015.
9
Characterization of Fc epsilon RI gamma in human natural killer cells.人类自然杀伤细胞中FcεRIγ的特性分析
Int Immunol. 1992 Aug;4(8):955-8. doi: 10.1093/intimm/4.8.955.
10
Kinetics of the appearance of Fc epsilon RI-bearing cells in interleukin-3-dependent mouse bone marrow cultures: correlation with histamine content and mast cell maturation.白细胞介素-3依赖的小鼠骨髓培养物中携带FcεRI的细胞出现的动力学：与组胺含量和肥大细胞成熟的相关性
Blood. 1992 Feb 15;79(4):972-80.

引用本文的文献

1
Interleukin-18 has an Important Role in Differentiation and Maturation of Mucosal Mast Cells.白细胞介素-18在黏膜肥大细胞的分化和成熟中起重要作用。
J Mucosal Immunol Res. 2018;2(1). Epub 2018 Jul 2.
2
Human eosinophils and mast cells: Birds of a feather flock together.人嗜酸性粒细胞和肥大细胞：物以类聚。
Immunol Rev. 2018 Mar;282(1):151-167. doi: 10.1111/imr.12638.
3
The antigen presentation function of bone marrow-derived mast cells is spatiotemporally restricted to a subset expressing high levels of cell surface FcepsilonRI and MHC II.骨髓来源的肥大细胞的抗原呈递功能在空间和时间上局限于表达高水平细胞表面 FcepsilonRI 和 MHC II 的亚群。
BMC Immunol. 2010 Jun 30;11:34. doi: 10.1186/1471-2172-11-34.
4
Evidence for a differential expression of the FcepsilonRIgamma chain in dendritic cells of atopic and nonatopic donors.特应性和非特应性供体树突状细胞中FcepsilonRIγ链差异表达的证据。
J Clin Invest. 2003 Apr;111(7):1047-56. doi: 10.1172/JCI15932.
5
Identification of Fc epsilon RIneg mast cells in mouse bone marrow cell cultures. Use of a monoclonal anti-p161 antibody.小鼠骨髓细胞培养物中FcεRI阴性肥大细胞的鉴定。单克隆抗-p161抗体的应用。
J Exp Med. 1995 Aug 1;182(2):575-9. doi: 10.1084/jem.182.2.575.

本文引用的文献

1
FcR gamma chain deletion results in pleiotrophic effector cell defects.FcRγ链缺失导致多效性效应细胞缺陷。
Cell. 1994 Feb 11;76(3):519-29. doi: 10.1016/0092-8674(94)90115-5.
2
Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals.特应性个体单核细胞上功能性高亲和力免疫球蛋白E受体（FcεRI）的表达。
J Exp Med. 1994 Feb 1;179(2):745-50. doi: 10.1084/jem.179.2.745.
3
Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene.通过靶向破坏高亲和力免疫球蛋白E受体α链基因消除过敏反应。
Cell. 1993 Dec 3;75(5):969-76. doi: 10.1016/0092-8674(93)90540-7.
4
High-affinity IgE receptor on eosinophils is involved in defence against parasites.嗜酸性粒细胞上的高亲和力IgE受体参与抵御寄生虫。
Nature. 1994 Jan 13;367(6459):183-6. doi: 10.1038/367183a0.
5
Fc receptors: rubor redux.Fc受体：炎症再现。
Cell. 1994 Aug 26;78(4):553-60. doi: 10.1016/0092-8674(94)90521-5.
6
B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells.B细胞刺激因子-1/白细胞介素-4信使核糖核酸由正常和转化的肥大细胞表达。
Cell. 1987 Aug 28;50(5):809-18. doi: 10.1016/0092-8674(87)90339-4.
7
Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism.阿贝尔森鼠白血病病毒诱导肥大细胞的肿瘤转化：通过非自分泌机制消除对白细胞介素-3的依赖性。
Cell. 1985 Jul;41(3):685-93. doi: 10.1016/s0092-8674(85)80049-0.
8
Murine B cell hybridomas bearing ligand-inducible Fc receptors for IgE.携带IgE配体诱导型Fc受体的小鼠B细胞杂交瘤。
J Immunol. 1986 Jun 15;136(12):4573-80.
9
A single amino acid in the glycosyl phosphatidylinositol attachment domain determines the membrane topology of Fc gamma RIII.糖基磷脂酰肌醇连接结构域中的单个氨基酸决定了FcγRIII的膜拓扑结构。
Nature. 1989 Dec 14;342(6251):805-7. doi: 10.1038/342805a0.
10
A macrophage Fc gamma receptor and the mast cell receptor for IgE share an identical subunit.巨噬细胞Fcγ受体和IgE的肥大细胞受体共有一个相同的亚基。
Nature. 1989 Oct 26;341(6244):752-4. doi: 10.1038/341752a0.

缺乏高亲和力免疫球蛋白E受体的肥大细胞中FcεRIγ信使核糖核酸不足。

Mast cells lacking the high affinity immunoglobulin E receptor are deficient in Fc epsilon RI gamma messenger RNA.

作者信息

Ryan J J, Kinzer C A, Paul W E

机构信息

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1892, USA.

出版信息

J Exp Med. 1995 Aug 1;182(2):567-74. doi: 10.1084/jem.182.2.567.

DOI:10.1084/jem.182.2.567
PMID:7629513
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2192112/
Abstract

A population of cells that express mast cell markers, including the membrane protein p161, but that lack expression of the high affinity IgE receptor, Fc epsilon RI, can be routinely grown from bone marrow. Ionomycin, but not IgE immune complexes, causes these cells to release serotonin and to express IL-3 and IL-13 mRNA, consistent with their being FC epsilon RI-deficient mast cells. These p161+/Fc epsilon RI- mast cells expressed normal amounts of Fc epsilon RI alpha and beta chain mRNA, but extremely low levels of Fc epsilon RI gamma chain mRNA. In addition, this novel mast cell population expressed CD3 zeta chain mRNA, which p161+/Fc epsilon RI+ mast cells did not. CD3 zeta stable transfectants of Abelson-murine leukemia virus-transformed p161+/Fc epsilon RI+ mast cells continued to express Fc epsilon RI. This strongly suggests that the failure of p161+/Fc epsilon RI- mast cells to express IgE receptors was not caused by the presence of CD3 zeta chain. Transfection of human Fc epsilon RI gamma cDNA into p161+/Fc epsilon RI- mast cells rescued IgE binding. These stable transfectants released serotonin in response to cross-linkage of Fc epsilon RI, demonstrating that the molecular defect of p161+/Fc epsilon RI- mast cells is indeed the loss of Fc epsilon RI gamma expression.

摘要

一群表达肥大细胞标志物（包括膜蛋白p161）但缺乏高亲和力IgE受体FcεRI表达的细胞可常规地从骨髓中培养出来。离子霉素而非IgE免疫复合物可使这些细胞释放5-羟色胺并表达IL-3和IL-13 mRNA，这与其作为FcεRI缺陷型肥大细胞相一致。这些p161+/FcεRI-肥大细胞表达正常量的FcεRIα和β链mRNA，但FcεRIγ链mRNA水平极低。此外，这种新型肥大细胞群体表达CD3ζ链mRNA，而p161+/FcεRI+肥大细胞则不表达。阿贝尔逊鼠白血病病毒转化的p161+/FcεRI+肥大细胞的CD3ζ稳定转染子继续表达FcεRI。这强烈表明p161+/FcεRI-肥大细胞未能表达IgE受体并非由CD3ζ链的存在所致。将人FcεRIγ cDNA转染到p161+/FcεRI-肥大细胞中可挽救IgE结合。这些稳定转染子在FcεRI交联时释放5-羟色胺，表明p161+/FcεRI-肥大细胞的分子缺陷确实是FcεRIγ表达缺失。