Melikov E M, Bairamova E O
A. I. Karaev Institute of Physiology, Academy of Sciences of the Azerbaidzhan, Baku.
Neurosci Behav Physiol. 1995 Mar-Apr;25(2):158-63. doi: 10.1007/BF02358587.
The influence of microinfusion of 5-HT, NE, and DA into the amygdalar nuclei on the accomplishment of conditioned reinforcing and conditioned trigger reflexes which are constituents of the CADR was studied in cats with a developed conditioned alimentary discrimination reflex (CADR) in response to two conditional light stimuli set apart on different sides of a box. It was established that 5-HT in doses of 30-50 micrograms in a volume of 5 microliters elicits inhibition; the same doses of NE, by contrast, induces the "hanging-up" of the animals on conditional and conditional--unconditional stimuli which possess the property of reinforcement during the execution of the CADR. The microinfusion of DA in doses of 30-60 micrograms recalls, from animal to animal, the action of 5-HT and NE. It is hypothesized that the inhibitory functions of 5-HT and the activating actions of NE in the amygdalar nuclei support this structure's control of reinforcing conditional and conditional--unconditional reflexes and the perception of the reinforcing action of conditional stimuli. It is hypothesized that the DAergic innervation of the amygdala does not participate directly in conditioned reflex activity.
在对置于箱子不同侧的两个条件性光刺激产生已建立的条件性食物辨别反射（CADR）的猫中，研究了向杏仁核微量注射5-羟色胺（5-HT）、去甲肾上腺素（NE）和多巴胺（DA）对构成CADR的条件性强化反射和条件性触发反射完成情况的影响。结果发现，体积为5微升、剂量为30 - 50微克的5-HT会引发抑制作用；相比之下，相同剂量的NE会使动物在CADR执行过程中，对具有强化特性的条件性和条件 - 非条件性刺激“僵持不动”。剂量为30 - 60微克的DA微量注射，在不同动物身上，其作用类似于5-HT和NE。据推测，5-HT的抑制功能以及NE在杏仁核中的激活作用，支持了该结构对强化性条件反射和条件 - 非条件反射的控制以及对条件性刺激强化作用的感知。据推测，杏仁核的多巴胺能神经支配不直接参与条件反射活动。
