[The monoaminergic control of amygdaloid nuclei of the reinforcing action of conditioned stimuli].

Microinfusions of 5-HT and NA (30-50 mcg; 5 mcl) into the amygdalar nuclei (the central nucleus) were found to induce, correspondingly, inhibition and enhancement of acquired forms of behaviour conditioned by reinforcing, goal-directed action of phasic and instrumental-situational stimuli. After DA microinfusions in doses of 30-60 mcg various alterations of conditioned activity were observed in different animals resembling the results of 5-HT or NA action. Inhibitory action of 5-HT and excitatory action of NA in the amygdala are supposed to provide a structural work of stimuli reinforcing value perception and trans-switching of the behaviour to the stimuli. It is assumed that such mental departures in humans as emotional dullness and increased automatism may be developed during an increased endogenous 5-HT release in the amygdala. On the contrary, delay at the intermediate goals and application of the main motive to subsidiary operations may be underlain by NA release.