Petrik P V, Gelabert H A, Moore W S, Quinones-Baldrich W, Law M M
Section of Vascular Surgery, University of California at Los Angeles School of Medicine 90024, USA.
Stroke. 1995 Aug;26(8):1409-14. doi: 10.1161/01.str.26.8.1409.
Intimal hyperplasia is the single most important cause of early restenosis after carotid endarterectomy. Cigarette smoking is an independent risk factor associated with peripheral vascular disease and cerebrovascular accidents. We undertook a dose-response experiment to determine the effect of cigarette smoke on development of intimal hyperplasia in a rat carotid artery intimal injury model.
Seventy-two rats were divided into six equal groups and underwent standardized balloon injury to the carotid artery. Each group received 0 (controls), 1, 2, 3, 6, or 8 cigarettes per day for 4 weeks. Resultant intimal hyperplasia was expressed as a percentage of original lumen replaced by intimal hyperplasia.
Percent intimal hyperplasia development (+/- SD) was as follows: controls (0 cigarettes per day), 17.7 +/- 13.2; 1 cigarette per day, 22.8 +/- 15.0; 2 cigarettes per day, 20.0 +/- 14.7; 3 cigarettes per day, 19.2 +/- 12.1; 6 cigarettes per day, 43.5 +/- 15.5; and 8 cigarettes per day, 36.7 +/- 9.8. Six and 8 cigarettes per day significantly increased the development of intimal hyperplasia after intimal injury (P < .01).
High-dose cigarette smoke accelerates development of intimal hyperplasia and may pose a significant risk factor in developing carotid restenosis.
内膜增生是颈动脉内膜剥脱术后早期再狭窄的唯一最重要原因。吸烟是与外周血管疾病和脑血管意外相关的独立危险因素。我们进行了一项剂量反应实验，以确定香烟烟雾对大鼠颈动脉内膜损伤模型中内膜增生发展的影响。
72只大鼠分为6组，每组数量相等，均接受标准化的颈动脉球囊损伤。每组大鼠在4周内每天分别接受0支（对照组）、1支、2支、3支、6支或8支香烟。最终的内膜增生情况以内膜增生所取代的原始管腔百分比表示。
内膜增生百分比（±标准差）如下：对照组（每天0支香烟），17.7±13.2；每天1支香烟，22.8±15.0；每天2支香烟，20.0±14.7；每天3支香烟，19.2±12.1；每天6支香烟，43.5±15.5；每天8支香烟，36.7±9.8。每天6支和8支香烟显著增加了内膜损伤后内膜增生的发展（P<0.01）。
高剂量香烟烟雾会加速内膜增生的发展，可能是颈动脉再狭窄发生的一个重要危险因素。
