Wahbi A M, Abdine H, Rafik A, Sadek H
Pharmazie. 1977 Nov;32(11):690-2.
The spectra produced by the acid treatment and alkaline treatment of streptomycin and dihydrostreptomycin have been investigated to obtain suitable methods for their determination. Mixtures of the two antibiotics have been successfully determined in the UV region. Thus, using the orthogonal function method, dihydrostreptomycin has been determined after acid treatment whereas streptomycin has been determined after alkaline treatment followed by immediate neutralization.
对链霉素和双氢链霉素经酸处理和碱处理后产生的光谱进行了研究,以获得合适的测定方法。已成功在紫外区域测定了这两种抗生素的混合物。因此,使用正交函数法,酸处理后测定双氢链霉素,而碱处理后立即中和再测定链霉素。