Falcone R A, Marcovitz P A, Perez J E, Dittrich H C, Hopkins W E, Armstrong W F
Department of Medicine, University of Michigan, Ann Arbor 48109, USA.
Am Heart J. 1995 Aug;130(2):254-8. doi: 10.1016/0002-8703(95)90437-9.
Albunex is an intravenous contrast agent that opacifies the left ventricle (LV). This study evaluated the effect of Albunex on the enhancement of LV endocardial border localization during dobutamine stress echocardiography (DSE). Albunex was infused in 30 patients at baseline and with low- and high-dosage dobutamine. Apical two- and four-chamber views were divided into six segments each, and enhancement of LV border localization was compared with precontrast images graded as follows: 0 = none; 1 = faint; or 2 = optimal. The mean grade and percentage of segments with optimal localization of LV endocardial borders were determined. There was a significant increase in enhancement with low- and high-dosage dobutamine when compared with baseline. Of 179 segments with suboptimal enhancement at baseline, 137 (77%) became optimal during DSE with Albunex. We conclude that Albunex improves localization of LV endocardial borders and that this localization is enhanced during DSE.
阿尔布奈克斯是一种使左心室显影的静脉造影剂。本研究评估了阿尔布奈克斯在多巴酚丁胺负荷超声心动图（DSE）期间对增强左心室心内膜边界定位的作用。在30例患者的基线期以及使用低剂量和高剂量多巴酚丁胺时输注阿尔布奈克斯。心尖二腔和四腔视图各分为六个节段，并将左心室边界定位的增强情况与造影前图像进行比较，分级如下：0 = 无增强；1 = 轻度增强；或2 = 最佳增强。确定左心室心内膜边界最佳定位节段的平均分级和百分比。与基线期相比，低剂量和高剂量多巴酚丁胺时增强情况有显著增加。在基线期增强效果欠佳的179个节段中，137个（77%）在使用阿尔布奈克斯的DSE期间变为最佳增强。我们得出结论，阿尔布奈克斯可改善左心室心内膜边界的定位，且在DSE期间这种定位会增强。
