Hickey M S, Weidner M D, Gavigan K E, Zheng D, Tyndall G L, Houmard J A
Human Performance Laboratory, East Carolina University, Greenville, North Carolina 27858, USA.
Am J Physiol. 1995 Jul;269(1 Pt 1):E150-4. doi: 10.1152/ajpendo.1995.269.1.E150.
The purpose of the present investigation was to determine the relationship between skeletal muscle characteristics, adiposity, and in vivo insulin action. Percutaneous muscle biopsies of the vastus lateralis (VL) and gastrocnemius (G) muscles were obtained from twenty-two sedentary male subjects. Insulin sensitivity (SI) and glucose effectiveness (SG) were determined from minimal model analysis, and indexes of regional and overall adiposity were obtained. SI was positively related to the citrate synthase activity from the VL (r = 0.50, P < 0.01) but unrelated to the citrate synthase activity from the G (r = 0.28). Similarly, SI was inversely related to the percentage of type IIb fibers in the VL (r = -0.47, P < 0.01) but unrelated to the percentage of type IIb fibers in the G (r = 0.06). SG was unrelated to fiber type, oxidative capacity, or adiposity. These data suggest that oxidative capacity and other characteristics related to VL skeletal muscle fiber type are determinants of in vivo insulin action but that this relationship cannot be extended to all muscle groups. Finally, neither skeletal muscle characteristics nor adiposity appears to be a determinant of SG in sedentary males.
本研究的目的是确定骨骼肌特征、肥胖与体内胰岛素作用之间的关系。从22名久坐不动的男性受试者身上获取了股外侧肌（VL）和腓肠肌（G）的经皮肌肉活检样本。通过最小模型分析确定胰岛素敏感性（SI）和葡萄糖效能（SG），并获得局部和整体肥胖的指标。SI与VL中的柠檬酸合酶活性呈正相关（r = 0.50，P < 0.01），但与G中的柠檬酸合酶活性无关（r = 0.28）。同样，SI与VL中IIb型纤维的百分比呈负相关（r = -0.47，P < 0.01），但与G中IIb型纤维的百分比无关（r = 0.06）。SG与纤维类型、氧化能力或肥胖无关。这些数据表明，氧化能力和与VL骨骼肌纤维类型相关的其他特征是体内胰岛素作用的决定因素，但这种关系不能扩展到所有肌肉群。最后，在久坐不动的男性中，骨骼肌特征和肥胖似乎都不是SG的决定因素。
