Karam C, Bourmayan C, Desnos M, Guérot C
Service de Cardiologie, Hôpital Boucicaut, Paris.
Ann Cardiol Angeiol (Paris). 1995 Apr;44(4):195-201.
Although the cardiovascular effects of hormone replacement therapy of menopause have been controversial for a long time, the benefit of this treatment currently appears to be well established, despite the methodological problems of most studies and the absence of definitive demonstration by a prospective randomized study. The mechanism of this favourable action appears to be multifactorial with, in particular, an improvement of the lipid profile. In the absence of any gynaecological contraindication, the combination of a natural oestrogen and a progestogen devoid of any androgenic effect therefore appears to be the preferable treatment in postmenopausal women, especially as its cardiological value is added to other important and clearly documented actions.
尽管更年期激素替代疗法的心血管效应长期以来一直存在争议，但尽管大多数研究存在方法学问题且缺乏前瞻性随机研究的确切证明，但目前这种治疗的益处似乎已得到充分证实。这种有利作用的机制似乎是多因素的，特别是脂质谱得到改善。因此，在没有任何妇科禁忌证的情况下，天然雌激素和无任何雄激素作用的孕激素联合使用似乎是绝经后女性的首选治疗方法，尤其是因为其心脏保护价值是在其他重要且有明确记录的作用之上的。
