Walkinshaw S, Pilling D, Spriggs A
Fetal Centre, Liverpool Maternity Hospital, U.K.
Prenat Diagn. 1994 Aug;14(8):663-7. doi: 10.1002/pd.1970140804.
The management of isolated fetal choroid plexus cysts remains controversial. We have prospectively studied 15,565 pregnancies at two large obstetric units for the presence of choroid plexus cysts. In all cases where cysts were present at 19 weeks' gestation or greater, and were multiple, bilateral or solitary and greater than 5 mm maximum diameter, women were offered amniocentesis or placental biopsy, irrespective of the presence or absence of other abnormalities. Choroid plexus cysts were present in 152 (0.98 per cent) of cases. Four cases (2.6 per cent) of autosomal trisomy (three of trisomy 18, one of trisomy 21) were detected on prenatal karyotyping. In all cases, choroid plexus cysts were the only detectable prenatal anomaly. This study and a review of other large studies do not support the view that isolated choroid plexus cysts are a benign variant, the risk of trisomy being 1 in 82. Until further evidence is available, we recommend that cases of isolated fetal choroid plexus cysts at 19 weeks' gestation or greater should be offered prenatal karyotyping.
孤立性胎儿脉络丛囊肿的处理仍存在争议。我们在两个大型产科单位对15565例妊娠进行了前瞻性研究，以观察脉络丛囊肿的情况。在所有妊娠19周及以上出现囊肿，且为多发、双侧或单发且最大直径大于5mm的病例中，无论有无其他异常，均建议孕妇进行羊膜穿刺术或胎盘活检。152例（0.98%）病例存在脉络丛囊肿。产前核型分析检测到4例（2.6%）常染色体三体（3例为18三体，1例为21三体）。所有病例中，脉络丛囊肿是唯一可检测到的产前异常。本研究以及对其他大型研究的综述并不支持孤立性脉络丛囊肿是良性变异的观点，三体风险为82分之一。在获得进一步证据之前，我们建议对妊娠19周及以上的孤立性胎儿脉络丛囊肿病例进行产前核型分析。
