Steele J, Stratford B
Logue School, Lancaster, England.
Am J Ment Retard. 1995 May;99(6):664-82.
The prevalence of Down syndrome by age and sex was established from questionnaires sent to heads of 30 registers in the United Kingdom covering a general population of over 7 million. Possible underascertainment and factors affecting prevalence were discussed. The overall prevalence of Down syndrome in the United Kingdom was 6.7 per 10,000 general population, representing approximately 30,000 affected individuals. Prevalence was also presented in 5-year age bands. We used two methods of projection and found no significant difference in their results. There was no indication of a sizable reduction in the future Down syndrome population. An incidence- and mortality-based projection method provided evidence that recent reductions in prevalence among the youngest age bands may be explained by changes in the maternal population.
通过向英国30个登记处负责人发送问卷，确定了唐氏综合征按年龄和性别的患病率，这些登记处覆盖了超过700万的普通人群。讨论了可能存在的漏报情况以及影响患病率的因素。英国唐氏综合征的总体患病率为每10000名普通人群中有6.7例，约有30000名患者。患病率也按5岁年龄组进行了呈现。我们使用了两种预测方法，发现结果没有显著差异。没有迹象表明未来唐氏综合征患者数量会大幅减少。一种基于发病率和死亡率的预测方法提供了证据，表明最年轻年龄组近期患病率的下降可能是由于孕产妇群体的变化所致。
