Alexander M, Ding Y, Foskett N, Petri H, Wandel C, Khwaja O
Roche Products Limited, United Kingdom of Great Britain and Northern Ireland.
Genesis Research Limited, USA.
J Intellect Disabil Res. 2016 Sep;60(9):874-8. doi: 10.1111/jir.12277. Epub 2016 Mar 28.
Aim was to estimate the age and sex-stratified prevalence of Down's syndrome (DS) in the United Kingdom (UK) general population using a large primary care database.
Data source was the Clinical Practice Research Datalink. We divided the number of individuals with a record of DS present on 01/07/2014 by the total number of individuals, and computed Wilson's confidence intervals. Prevalence by age and sex was represented using local linear smoothing plots.
On July 1(st) 2014, 1159 females and 1317 males with DS were present in the data, corresponding to a prevalence of 5.9 per 10 000 (95% CI: 5.5; 6.2) in females and 6.8 (6.5; 7.2) per 10 000 in males. Prevalence of DS was increased in individuals aged 40 to 55 years compared to adjacent age groups.
A relative peak prevalence of DS at age 40-55 years may be attributed to the combined effects of a rise in life expectancy and the still limited availability of selective abortion.
目的是利用一个大型初级保健数据库估算英国普通人群中唐氏综合征（DS）按年龄和性别的分层患病率。
数据来源为临床实践研究数据链。我们将2014年7月1日有DS记录的个体数量除以个体总数，并计算威尔逊置信区间。按年龄和性别划分的患病率用局部线性平滑图表示。
2014年7月1日，数据中有1159名患有DS的女性和1317名患有DS的男性，女性患病率为每10000人中有5.9例（95%置信区间：5.5；6.2），男性患病率为每10000人中有6.8例（6.5；7.2）。与相邻年龄组相比，40至55岁个体的DS患病率有所增加。
40 - 55岁时DS患病率相对较高，这可能归因于预期寿命延长和选择性堕胎的可及性仍然有限的综合影响。
