Sklan D, Trifon S, Kedar O, Vaisman N, Berner Y
Faculty of Agriculture, Hebrew University, Rehovot, Israel.
Br J Nutr. 1995 Jun;73(6):889-95. doi: 10.1079/bjn19950094.
Leucocytes from subjects from 0 to 80 years old were separated into mononuclear and granulocyte fractions and the retinoids and retinoid-binding fractions were examined. Both leucocyte fractions were found to contain retinol, retinoic acid and an additional retinoid; retinoic acid comprised 40% of retinoids in some samples. The protein fractions containing retinoids included a 200 kDa protein and several 14-18 kDa proteins. Plasma concentrations of retinol changed little with increasing age. In contrast, leucocyte concentrations of retinoids and retinoid-binding proteins increased quadratically with age. However, in granulocytes from young children retinoids were almost undetectable.
将0至80岁受试者的白细胞分离为单核细胞和粒细胞组分，并检测类视黄醇和类视黄醇结合组分。发现这两种白细胞组分均含有视黄醇、视黄酸和另一种类视黄醇；视黄酸在某些样本中占类视黄醇的40%。含有类视黄醇的蛋白质组分包括一种200 kDa的蛋白质和几种14 - 18 kDa的蛋白质。视黄醇的血浆浓度随年龄增长变化不大。相比之下，类视黄醇和类视黄醇结合蛋白的白细胞浓度随年龄呈二次方增加。然而，幼儿粒细胞中的类视黄醇几乎无法检测到。
