Young H, Carnochan P, Zweit J, Babich J, Cherry S, Ott R
Joint Department of Physics, Royal Marsden Hospital, Sutton, Surrey, United Kingdom.
J Nucl Biol Med (1991). 1994 Dec;38(4 Suppl 1):89-91.
Copper (II)-pyruvaldehyde bis (N-4-methylthiosemicarbazone) (Cu-PTSM) labelled with 62Cu or 64Cu is currently under investigation as a radiotracer for imaging the distribution of blood flow with positron emission tomography (PET). The application of a simple trapped tracer model in conjunction with tissue uptake and continuous arterial sampling to estimate blood flow has been compared with the 57Co-microsphere method in the rat. After intraventricular injection the cumulative arterial function for 64Cu increased progressively due to the presence of circulating non lipophilic complexes. The cumulative function for lipophilic 64Cu-PTSM extracted in n-octanol plateaued at levels corresponding to those reached by 57Co-microspheres. No consistent disagreement was found between cardiac output and blood flow estimated by 64Cu-PTSM and 57Co-microspheres in low to moderate flow tissues: muscle (0.08, 0.07 mL/min/g; 64Cu mean, 57Co mean), brain (0.52, 0.43 mL/min/g) and kidney (2.29, 2.45 mL/min/g). However, 64Cu-PTSM underestimated blood flow measured by 57Co-microspheres in myocardium (4.09, 6.55 mL/min/g). A simple tissue trapping model may therefore be suitable for the derivation of blood flow estimates in low to moderate flow tissues using 62,64Cu-PTSM, PET imaging and continuous arterial sampling with n-octanol extraction.
用62Cu或64Cu标记的铜（II）-丙酮醛双（N-4-甲基硫代半卡巴腙）（Cu-PTSM）目前正在作为一种放射性示踪剂进行研究，用于正电子发射断层扫描（PET）成像血流分布。已将一种简单的滞留示踪剂模型与组织摄取和连续动脉采样相结合以估计血流的方法，与大鼠中的57Co微球法进行了比较。脑室内注射后，由于循环中存在非亲脂性复合物，64Cu的累积动脉功能逐渐增加。在正辛醇中提取的亲脂性64Cu-PTSM的累积功能在与57Co微球达到的水平相对应的水平上趋于平稳。在低至中等血流组织中，64Cu-PTSM和57Co微球估计的心输出量和血流之间未发现一致的差异：肌肉（0.08，0.07 mL/min/g；64Cu均值，57Co均值）、脑（0.52，0.43 mL/min/g）和肾脏（2.29，2.45 mL/min/g）。然而，64Cu-PTSM低估了心肌中57Co微球测量的血流（4.09，6.55 mL/min/g）。因此，一个简单的组织滞留模型可能适用于使用62,64Cu-PTSM、PET成像以及正辛醇提取的连续动脉采样来推导低至中等血流组织中的血流估计值。
