Verhoef G E, Pittaluga S, De Wolf-Peeters C, Boogaerts M A
Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium.
Ann Hematol. 1995 Jul;71(1):3-11. doi: 10.1007/BF01696227.
Guidelines for the definition and diagnosis of myelodysplasia were set out by the French-American-British Cooperative group (FAB), and the resulting framework has greatly helped the now very large number of workers in many scientific disciplines who are actively investigating the myelodysplastic syndromes (MDS). Most patients with MDS can be readily classified into clinically relevant subgroups by correlation of clinical findings with the findings from well-prepared peripheral blood and bone marrow specimens. However, there are several areas where the standard morphological features are insensitive, but integration of these parameters with histology and cytogenetic and molecular techniques may help us in understanding this fascinating disease.
法国 - 美国 - 英国合作组（FAB）制定了骨髓发育异常的定义和诊断指南，由此形成的框架极大地帮助了众多来自许多科学学科、正在积极研究骨髓增生异常综合征（MDS）的科研人员。通过将临床发现与精心制备的外周血和骨髓标本的检查结果相关联，大多数MDS患者能够很容易地被归入具有临床相关性的亚组。然而，在几个方面，标准形态学特征并不敏感，但将这些参数与组织学、细胞遗传学和分子技术相结合，可能有助于我们理解这种引人入胜的疾病。
