Chao C L, Lee Y T, Chieng P U, Ho F M, Shiau Y C, Shen S J, Su C T, Huang P J
Department of Internal Medicine, National Taiwan University Hospital, Taipei, R.O.C.
J Formos Med Assoc. 1994 Nov-Dec;93(11-12):906-10.
Dipyridamole thallium-201 imaging, using single-photon emission computed tomography, was evaluated for its safety and diagnostic efficacy in 109 patients with angiographically documented coronary artery disease and 35 normal subjects. The most common side effects after the intravenous administration of dipyridamole thallium-201 (0.56 mg/kg) included chest pain in 41 patients, dizziness in 20 patients, headache in 16 patients, and ST segment depression > or = 1 mm in 15 patients. Aminophylline was required to reverse the side-effects in 46 patients, and 45 of the 46 patients experienced complete relief of symptoms. Of the 109 patients with coronary artery disease, 104 had abnormal dipyridamole thallium images. The per patient sensitivity was 95%. Of the 35 normal subjects, 27 had normal thallium images. The per patient specificity was 77%. The sensitivity and specificity for the individual vessels were 84% and 87% for the left anterior descending artery, 67% and 97% for the left circumflex artery, and 89% and 85% for the right coronary artery, respectively. Dipyridamole thallium-201 imaging is a relatively safe noninvasive method and is an effective alternative to exercise thallium-201 scintigraphy for the diagnosis of coronary artery disease.
采用单光子发射计算机断层扫描技术对109例经血管造影证实患有冠状动脉疾病的患者和35名正常受试者进行了双嘧达莫铊-201显像，评估其安全性和诊断效能。静脉注射双嘧达莫铊-201（0.56mg/kg）后最常见的副作用包括41例患者出现胸痛，20例患者出现头晕，16例患者出现头痛，15例患者ST段压低≥1mm。46例患者需要使用氨茶碱来逆转副作用，其中45例症状完全缓解。109例冠状动脉疾病患者中，104例双嘧达莫铊显像异常。患者个体敏感性为95%。35名正常受试者中，27例铊显像正常。患者个体特异性为77%。左前降支、左旋支和右冠状动脉的血管个体敏感性和特异性分别为84%和87%、67%和97%、89%和85%。双嘧达莫铊-201显像是一种相对安全的非侵入性方法，是运动铊-201闪烁显像诊断冠状动脉疾病的有效替代方法。
