Yonezawa Y, Yoshikawa J, Shakudo M, Okumachi F, Shiratori K, Koizumi K, Akasaka T, Yoshida K, Ikekubo K
Department of Cardiology, Kobe General Hospital.
J Cardiol. 1995 Jan;25(1):9-13.
Adenosine triphosphate (ATP) is an alternative to dipyridamole or adenosine in thallium-201 myocardial scintigraphy. However, the optimal dose of ATP has not been determined. A Doppler guide wire study showed the coronary flow velocity at a dose of 0.15 mg/kg of ATP was equal or higher than that at 0.14 mg/kg of adenosine or 0.56 mg/kg of dipyridamole. ATP was given intravenously to 67 patients with coronary artery disease at 0.15 mg/kg/min for 6 min. Thallium-201 was injected at 3 min, followed by immediate and delayed (3 hrs) tomographic imaging. There was no serious side effect during examination, although chest pain (26%), dyspnea (17%), and flushing (33%) were common. The sensitivity and specificity to detect coronary artery disease were 98 and 100%, respectively. The sensitivity to detect left anterior descending artery, left circumflex artery, and right coronary artery lesions was 94, 59 and 77%, respectively. ATP loading thallium-201 scintigraphy provides an accurate diagnosis of coronary artery disease. The optimal dose of ATP is 0.15 mg/kg/min for 6 min.
在铊-201心肌闪烁显像中，三磷酸腺苷（ATP）是双嘧达莫或腺苷的替代物。然而，ATP的最佳剂量尚未确定。一项多普勒导丝研究表明，ATP剂量为0.15mg/kg时的冠状动脉血流速度等于或高于腺苷剂量为0.14mg/kg或双嘧达莫剂量为0.56mg/kg时的冠状动脉血流速度。对67例冠心病患者静脉注射ATP，剂量为0.15mg/（kg·min），持续6分钟。在3分钟时注射铊-201，随后立即进行断层显像和延迟（3小时）断层显像。检查期间虽有胸痛（26%）、呼吸困难（17%）和面部潮红（33%）等常见情况，但无严重副作用。检测冠心病的敏感性和特异性分别为98%和100%。检测左前降支、左旋支和右冠状动脉病变的敏感性分别为94%、59%和77%。ATP负荷铊-201闪烁显像可准确诊断冠心病。ATP的最佳剂量为0.15mg/（kg·min），持续6分钟。
