Olson L G, King M T, Hensley M J, Saunders N A
Discipline of Medicine, University of Newcastle, New South Wales, Australia.
Am J Respir Crit Care Med. 1995 Aug;152(2):717-20. doi: 10.1164/ajrccm.152.2.7633732.
Four hundred forty-one subjects 34 to 69 yr of age were recruited from a random sample of the community. They answered a questionnaire and were monitored in their homes for sleep-disordered breathing (SDB). This report concerns the association between observed SDB and arterial hypertension and vascular disease. Hypertension was defined as self-report of a diagnosis of hypertension made by a physician, current treatment for hypertension, or a systolic pressure greater than 150 mm Hg or a diastolic pressure greater than 90 mm Hg. Coronary artery disease was defined by self-report of angina or myocardial infarction of "heart attack." There were few cases of stroke or claudication, and a category of "occlusive vascular disease" was defined by self-report of coronary artery disease or of "blocked arteries" or stroke. Subjects were classified as snorers (n = 289) or nonsnorers (n = 73) by self-report of regular snoring, and as having SDB (n = 79) if more than 15 abnormal respiratory events were recorded per hour of recording. There were significant increases in the prevalence of hypertension, coronary artery disease, and occlusive vascular disease from nonsnorers (26, 7, and 10%, respectively) through snorers (39, 12, and 17%) to subjects with SDB (57, 20, and 28%). The crude odds ratio for SDB versus nonsnorers was 3.8 (95% CI, 1.9 to 7.5) for hypertension, 3.5 (1.2 to 10.0) for coronary artery disease, and 3.7 (1.5 to 9.1) for occlusive vascular disease.(ABSTRACT TRUNCATED AT 250 WORDS)
从社区随机抽样招募了441名年龄在34至69岁之间的受试者。他们回答了一份问卷,并在家中接受睡眠呼吸紊乱(SDB)监测。本报告关注观察到的SDB与动脉高血压和血管疾病之间的关联。高血压定义为医生诊断为高血压的自我报告、当前高血压治疗情况,或收缩压大于150 mmHg或舒张压大于90 mmHg。冠状动脉疾病定义为心绞痛或“心脏病发作”的心肌梗死的自我报告。中风或跛行病例较少,“闭塞性血管疾病”类别由冠状动脉疾病、“动脉阻塞”或中风的自我报告定义。根据是否经常打鼾的自我报告,受试者被分为打鼾者(n = 289)或非打鼾者(n = 73),如果每小时记录的异常呼吸事件超过15次,则被归类为患有SDB(n = 79)。从非打鼾者(分别为26%、7%和10%)到打鼾者(39%、12%和17%)再到患有SDB的受试者(57%、20%和28%),高血压、冠状动脉疾病和闭塞性血管疾病的患病率显著增加。SDB与非打鼾者相比,高血压的粗比值比为3.8(95%CI,1.9至7.5),冠状动脉疾病为3.5(1.2至10.0),闭塞性血管疾病为3.7(1.5至9.1)。(摘要截短于250字)