Muntinga J H, Gels M E, Terpstra W F, Visser K R
Department of Medical Physiology, University of Groningen, The Netherlands.
Med Eng Phys. 1995 Jun;17(4):264-72. doi: 10.1016/1350-4533(95)90851-2.
Studies concerning vascular changes in hypertension and exercise have shown an increasing need to investigate the properties of a complete vascular bed in vivo. In this study, the repeatability of a non-invasive method for quantifying properties of the vascular bed of an upper arm segment, was investigated in two groups of volunteers (age 22-55 years). One group of subjects (n = 9) were measured twice at a 15 min interval. The other group (n = 8) were measured 4 times with each subject measured daily at the same time. The estimated quantities included the arterial and venous blood volume, the static arterial compliance, the myogenic response of the arm veins and the extravascular fluid volume of the tissue under an occluding cuff at the upper arm. They not only describe properties of the arterial vascular bed as a whole but also of different sized arteries functioning at different intra-arterial pressure. They were derived from the fluid shifts under the occluding cuff that arise when cuff pressure changes, as determined by electrical impedance and blood pressure measurements. The repeatability of the method was well within the physiologically acceptable range and of the same order of magnitude as that of established methods. Established methods however, provide less information about the properties of a vascular bed and result in controversial estimates of the dynamic arterial compliance. Furthermore, the method eliminates the need to match subjects in comparative studies for arterial blood pressure. These features and the sensitivity of the method for (patho)physiological changes, offer the possibility to investigate in vivo many still unknown aspects of the peripheral circulation.
关于高血压和运动时血管变化的研究表明，越来越有必要在体内研究完整血管床的特性。在本研究中，对两组志愿者（年龄22 - 55岁）上臂段血管床特性定量的非侵入性方法的可重复性进行了研究。一组受试者（n = 9）每隔15分钟测量两次。另一组（n = 8）测量4次，每个受试者每天在同一时间测量。估计的量包括动脉和静脉血容量、静态动脉顺应性、手臂静脉的肌源性反应以及上臂袖带下方组织的血管外液体积。它们不仅描述了整个动脉血管床的特性，还描述了在不同动脉内压下起作用的不同大小动脉的特性。它们是由袖带压力变化时袖带下方的液体转移得出的，袖带压力变化通过电阻抗和血压测量来确定。该方法的可重复性完全在生理可接受范围内，且与现有方法的量级相同。然而，现有方法提供的关于血管床特性的信息较少，并且对动态动脉顺应性的估计存在争议。此外，该方法无需在比较研究中匹配受试者的动脉血压。这些特性以及该方法对（病理）生理变化的敏感性，为在体内研究外周循环中许多仍未知的方面提供了可能性。
