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一种用于在自由活动大鼠中对周围神经进行电刺激的小型袖带电极。

A miniaturized cuff electrode for electrical stimulation of peripheral nerves in the freely moving rat.

作者信息

Jellema T, Teepen J L

机构信息

Tilburg University, Department of Psychology, The Netherlands.

出版信息

Brain Res Bull. 1995;37(5):551-4. doi: 10.1016/0361-9230(95)00035-d.

DOI:10.1016/0361-9230(95)00035-d
PMID:7633905
Abstract

A bipolar cuff electrode for electrical stimulation of small diameter peripheral nerves is described. The cuff is made of a highly flexible rubber-impression material, and the electrode assembly is suited for chronic implantation. Its manual construction is easy and reliable, utilizing only simple tools. The cuff completely envelopes nerves of varying diameter and requires a minimal amount of manipulations of the nerve, thereby reducing the chance of surgical trauma. The snug envelope prevents the nerve from drying, and minimizes shunting between the two leads by extracellular fluids. Small outer dimensions were achieved: 1.4 x 1.1 x 2.3 mm (width x height x length) when used with nerves of 1 mm diameter, which minimizes pressure and damage to surrounding tissues. Morphometric analysis of nerves enclosed in cuffs for 28-30 h revealed a small decrease in the number of large-diameter fibers. Stimulation thresholds remained, however, constant throughout the experiments.

摘要

本文描述了一种用于电刺激小直径外周神经的双极袖套电极。该袖套由高柔韧性的橡胶印模材料制成,电极组件适合长期植入。其手工制作简便可靠,仅需使用简单工具。该袖套能完全包裹不同直径的神经,且对神经的操作极少,从而降低了手术创伤的几率。紧密的包裹可防止神经干燥,并使细胞外液在两根引线之间的分流降至最低。该电极的外部尺寸很小:与直径为1毫米的神经配合使用时为1.4×1.1×2.3毫米(宽×高×长),这将对周围组织的压力和损伤降至最低。对置于袖套内28至30小时的神经进行形态计量分析发现,大直径纤维的数量略有减少。然而,在整个实验过程中,刺激阈值保持恒定。

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