Fukai I, Masaoka A, Yamakawa Y, Niwa H, Eimoto T
Second Department of Surgery, Nagoya City University Medical School, Japan.
Chest. 1995 Aug;108(2):574-5. doi: 10.1378/chest.108.2.574.
A case of mediastinal malignant epithelioid schwannoma (MES) is reported. The tumor probably arose in the vagal nerve, and the trachea was involved. A few months after excision of the primary tumor, multiple metastases appeared in lung, cervical spine, and neck lymph nodes. Microscopically, the tumor showed a highly cellular area resembling melanoma or carcinoma. Immunolabeling was done for S-100 protein, keratin, and melanoma-associated antigen. Examination of the entire lesion and in situ characteristics of the tumor involving the vagal nerve were helpful in making the correct diagnosis. Mediastinal MES, to our knowledge, has not been reported to date in the English-language medical literature.
报告了一例纵隔恶性上皮样施万细胞瘤（MES）。肿瘤可能起源于迷走神经，并累及气管。原发肿瘤切除几个月后，肺、颈椎和颈部淋巴结出现多处转移。显微镜下，肿瘤显示出一个细胞高度密集的区域，类似黑色素瘤或癌。对S-100蛋白、角蛋白和黑色素瘤相关抗原进行了免疫标记。对整个病变以及累及迷走神经的肿瘤原位特征进行检查有助于做出正确诊断。据我们所知，纵隔MES在英文医学文献中迄今尚未见报道。
