Alemayehu S, Bergey G K, Barry E, Krumholz A, Wolf A, Fleming C P, Frear E J
Department of Neurology, University of Maryland School of Medicine, Baltimore, USA.
Epilepsia. 1995 Aug;36(8):824-30. doi: 10.1111/j.1528-1157.1995.tb01621.x.
Although most panic attacks appear to be primary psychiatric disturbances, some evidence suggests a biologic basis for panic disorder, possibly associated with temporal lobe dysfunction. Fear is a common affective change associated with some complex partial seizures (CPS) originating from the right temporal lobe. We describe a previously unreported association between panic attacks and seizures originating from the parietal lobe in 2 patients with right parietal lobe tumors. Intracranial monitoring documented correlations between the symptoms of fear and restricted regional parietal cortical discharges. Surgical resections of the lesions (one total, one subtotal) resulted in complete recovery or improvement.
虽然大多数惊恐发作似乎是原发性精神障碍，但一些证据表明惊恐障碍存在生物学基础，可能与颞叶功能障碍有关。恐惧是一种常见的情感变化，与一些起源于右侧颞叶的复杂部分性发作（CPS）有关。我们描述了2例右侧顶叶肿瘤患者中惊恐发作与起源于顶叶的癫痫发作之间一种此前未报告的关联。颅内监测记录了恐惧症状与局部顶叶皮质放电受限之间的相关性。病变的手术切除（1例全切，1例次全切）导致完全康复或病情改善。
