Byers T J, Beggs A H, McNally E M, Kunkel L M
Department of Physiology and Biophysics, Indiana University School of Medicine, Indianapolis 46202, USA.
FEBS Lett. 1995 Jul 24;368(3):500-4. doi: 10.1016/0014-5793(95)00722-l.
Actin-crosslinking proteins link F-actin into the bundles and networks that constitute the cytoskeleton. Dystrophin, beta-spectrin, alpha-actinin, ABP-120, ABP-280, and fimbrin share homologous actin-binding domains and comprise an actin crosslinker superfamily. We have identified a novel member of this superfamily (ACF7) using a degenerate primer-mediated PCR strategy that was optimized to resolve less-abundant superfamily sequences. The ACF7 gene is on human chromosome 1 and hybridizes to high molecular weight bands on northern blots. Sequence comparisons argue that ACF7 does not fit into one of the existing families, but represents a new class within the superfamily.
