陆地蜗牛玛瑙螺的复杂回避行为及其神经化学调控

Complex avoidance behaviour and its neurochemical regulation in the land snail Cepaea nemoralis.

Dyakonova V E, Elofsson R, Carlberg M, Sakharov D A

Institute of Developmental Biology, Russian Academy of Sciences, Moscow.

Gen Pharmacol. 1995 Jul;26(4):773-7. doi: 10.1016/0306-3623(94)00263-m.

Abstract

In hot plate experiments, the pulmonate land snail Cepaea nemoralis displays a biphasic passive/active avoidance behaviour composed of retraction and subsequent searching mediated by antagonistic muscular systems. The switch, between the behaviours, is under neuronal control. 2. Leu- and met-enkephalin, as well as FMRFamide-antiserum, attenuated the retraction response and potentiated the searching behaviour. Opposite effects were achieved by injection of antisera to the enkephalins. 3. Both retraction and searching behaviours were potentiated by 5-HT. Methysergide antagonized the effects of the enkephalins on the searching behaviour. 4. We conclude that endogenous opioids act antagonistic to FMRFamide in the neuronally controlled switch between passive and active avoidance behaviour.

摘要

在热板实验中，肺螺亚纲的陆地蜗牛玛瑙螺表现出一种双相被动/主动回避行为，该行为由收缩以及随后由拮抗肌肉系统介导的搜索组成。行为之间的转换受神经控制。2. 亮氨酸脑啡肽和甲硫氨酸脑啡肽以及FMRF酰胺抗血清减弱了收缩反应并增强了搜索行为。通过注射脑啡肽抗血清则产生相反的效果。3. 5-羟色胺增强了收缩和搜索行为。麦角新碱拮抗了脑啡肽对搜索行为的影响。4. 我们得出结论，内源性阿片类物质在被动和主动回避行为之间的神经控制转换中与FMRF酰胺起拮抗作用。