Ingleton P M, Hazon N, Ho P M, Martin T J, Danks J A
Institute of Endocrinology, Medical School, Sheffield, United Kingdom.
Gen Comp Endocrinol. 1995 May;98(2):211-8. doi: 10.1006/gcen.1995.1062.
We have used antiserum to human parathyroid hormone-related protein (PTHrP) (1-16) to examine tissues and plasma of the dogfish (Scyliorhinus canicula) for the presence of immunoreactive PTHrP (irPTHrP). The plasma contained high concentrations of irPTHrP (9.34 +/- 0.37 pM), comparable to levels in humans with hypercalcaemia of malignancy. Other tissues with irPTHrP included brain neurones; epithelial cells of the saccus vasculosus, kidney, rectal gland and choroid plexus; and cells of the pituitary pars distalis. PTHrP was not detected in gut, skin, oviduct, and gill epithelia, nor in branchial cartilage. The principal source(s) of plasma PTHrP is not known.
我们使用抗人甲状旁腺激素相关蛋白（PTHrP）（1 - 16）抗血清来检测鲨鱼（Scyliorhinus canicula）的组织和血浆中是否存在免疫反应性PTHrP（irPTHrP）。血浆中含有高浓度的irPTHrP（9.34±0.37 pM），与恶性肿瘤高钙血症患者的水平相当。其他含有irPTHrP的组织包括脑神经元；血管囊、肾脏、直肠腺和脉络丛的上皮细胞；以及垂体远侧部的细胞。在肠道、皮肤、输卵管、鳃上皮以及鳃软骨中未检测到PTHrP。血浆PTHrP的主要来源尚不清楚。
