Niikura H, Sasano H, Matsunaga G, Watanabe K, Ito K, Sato S, Yajima A
Department of Obstetrics and Gynecology and Pathology, Tohoku University School of Medicine, Sendai, Japan.
Hum Pathol. 1995 Aug;26(8):892-6. doi: 10.1016/0046-8177(95)90013-6.
We report here a retrospective study of epidermal growth factor receptor (EGFR) expression in 140 patients with human endometrioid endometrial carcinoma (median period of follow-up, 43.8 months; ranging from 1 to 155 months). Tumor specimens were immunohistochemically examined for the overexpression of EGFR, and the correlation among EGFR status, various clinicopathologic parameters, and prognosis was statistically evaluated. Monoclonal antibody (clone 31 G 7), which recognizes the extracellular domain of the EGFR molecule, was used for immunostaining. Ninety-four of 140 cases were immunohistochemically positive for EGFR (67.1%). The presence or absence of EGFR did not correlate with surgical stage, depth of myometrial invasion (DI), or lymph node involvement, but did correlate with histological grade and patient's age. Furthermore, patients with EGFR-positive endometrial carcinoma had a statistically significant shorter length of survival than those with EGFR-negative tumors (P = .018). This trend is more apparent among the patients more than 50 years old (P = .003). When adjusted for surgical stage, DI, and patient age, EGFR status retained prognostic value by multivariate analysis. However, when adjusted for surgical stage, histological grade, DI, and patient age, EGFR status failed to retain prognostic value by multivariate analysis. The results of this study suggest that EGFR expression is correlated with histological grade and greater invasiveness of human endometrioid endometrial carcinoma.
我们在此报告一项对140例人子宫内膜样腺癌患者（中位随访期43.8个月；范围为1至155个月）表皮生长因子受体（EGFR）表达的回顾性研究。对肿瘤标本进行免疫组织化学检查以检测EGFR的过表达，并对EGFR状态、各种临床病理参数和预后之间的相关性进行统计学评估。使用识别EGFR分子细胞外结构域的单克隆抗体（克隆31G7）进行免疫染色。140例病例中有94例EGFR免疫组织化学呈阳性（67.1%）。EGFR的存在与否与手术分期、肌层浸润深度（DI）或淋巴结受累无关，但与组织学分级和患者年龄相关。此外，EGFR阳性子宫内膜癌患者的生存时间在统计学上显著短于EGFR阴性肿瘤患者（P = 0.018）。这种趋势在50岁以上的患者中更为明显（P = 0.003）。在对手术分期、DI和患者年龄进行校正后，EGFR状态在多变量分析中仍保留预后价值。然而，在对手术分期、组织学分级、DI和患者年龄进行校正后，EGFR状态在多变量分析中未能保留预后价值。本研究结果表明，EGFR表达与人类子宫内膜样腺癌的组织学分级和更强的侵袭性相关。
