Ford D, Bliss J M, Swerdlow A J, Armstrong B K, Franceschi S, Green A, Holly E A, Mack T, MacKie R M, Osterlind A
Institute of Cancer Research, London, UK.
Int J Cancer. 1995 Aug 9;62(4):377-81. doi: 10.1002/ijc.2910620403.
In a combined analysis of 2952 melanoma patients and 3618 controls from 8 case-control studies in white populations the risk of cutaneous melanoma was 2.24-fold higher (95% CI, 1.76-2.86) in subjects who reported at least one affected first-degree relative than in subjects who did not. There was no evidence for heterogeneity in the relative risk between the studies, which were from a wide range of latitudes and hence degrees of sun exposure. The effect of family history on melanoma risk was independent of age, naevus count, hair and eye colour, and freckling. There was no evidence for a relationship between family history and primary site of melanoma but there was some suggestion that the familial patients were more likely to have superficial spreading melanoma or lentigo maligna melanoma than acral lentiginous melanoma or nodular melanoma.
在一项对白人人群中8项病例对照研究的2952例黑色素瘤患者和3618例对照进行的综合分析中，报告至少有一位一级亲属患黑色素瘤的受试者患皮肤黑色素瘤的风险比未报告的受试者高2.24倍（95%置信区间，1.76 - 2.86）。这些研究来自广泛的纬度范围，因此阳光照射程度各不相同，但在各研究之间的相对风险中没有异质性证据。家族史对黑色素瘤风险的影响独立于年龄、痣的数量、头发和眼睛颜色以及雀斑。没有证据表明家族史与黑色素瘤的原发部位之间存在关联，但有一些迹象表明，家族性患者比肢端雀斑样痣黑色素瘤或结节性黑色素瘤更易患浅表扩散性黑色素瘤或恶性雀斑样痣黑色素瘤。
