Yeo A E, Rieckmann K H
Army Malaria Research Unit, University of Sydney, NSW, Australia.
Int J Parasitol. 1995 Apr;25(4):531-2. doi: 10.1016/0020-7519(94)00119-9.
The minimum inhibitory concentration, MIC, of azithromycin was determined for 2 isolates of Plasmodium falciparum at 48 and 96 h. The MIC at 48 h for the K1 and FC isolates were 6.2 and 8.7 micrograms/ml, respectively. At 96 h, the MIC decreased to 0.08 microgram/ml for the K1 isolate and 0.04 microgram/ml for the FC isolate. The marked reduction in the MIC values between the first and second asexual erythrocytic cycles suggests that the drug acts slowly and that it may have to be used in combination with a faster acting drug.
测定了阿奇霉素对2株恶性疟原虫在48小时和96小时时的最低抑菌浓度（MIC）。K1株和FC株在48小时时的MIC分别为6.2微克/毫升和8.7微克/毫升。在96小时时，K1株的MIC降至0.08微克/毫升，FC株的MIC降至0.04微克/毫升。在第一个和第二个无性红细胞周期之间MIC值的显著降低表明该药物作用缓慢，可能必须与作用更快的药物联合使用。
