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不同材料的眼部植入物对外照射放射治疗剂量测定的影响。

Effect of ocular implants of different materials on the dosimetry of external beam radiation therapy.

作者信息

Fontenla D P, Ahmad M, Chui C S, McCormick B, Abramson D H, Kutcher G J

机构信息

Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

出版信息

Int J Radiat Oncol Biol Phys. 1995 Jul 30;32(5):1477-80. doi: 10.1016/0360-3016(94)00611-N.

Abstract

PURPOSE

To study the attenuation and scattering effects of ocular implants, made from different materials, on the dose distributions of a 6 MV photon beam, and 6, 9, and 12 MeV electron beams used in orbital radiotherapy.

METHODS AND MATERIALS

Central axis depth-dose measurements were performed in a polystyrene phantom with embedded spherical ocular implants using film dosimetry of a 6 MV photon beam and electron beams of 6, 9, and 12 MeV energy. The isodose distributions were also calculated by a computerized treatment planning system using computerized tomography (CT) scans of a polystyrene phantom that had silicone, acrylic, and hydroxyapatite ocular implants placed into it.

RESULTS

Electron beam dose distributions display distortions both on the measured and calculated data. This effect is most accentuated for the hydroxyapatite implants, for which the transmissions through ocular implants are on the order of 93% for the 6 MV photon beam, and range from 60% for 6 MeV electrons to 90% for 12 MeV electrons.

CONCLUSION

We studied the effect of ocular implants of various materials, embedded in a polystyrene phantom, on the dose distributions of a 6 MV photon beam, and 6, 9, and 12 MeV electron beams. Our investigations show that while 6 MV photons experience only a few percent attenuation, lower energy electron beam with 60% transmission is not a suitable choice of treating tumors behind the ocular implants.

摘要

目的

研究由不同材料制成的眼部植入物对用于眼眶放射治疗的6兆伏光子束以及6、9和12兆伏电子束剂量分布的衰减和散射效应。

方法和材料

使用6兆伏光子束以及能量为6、9和12兆伏的电子束的胶片剂量测定法,在嵌入球形眼部植入物的聚苯乙烯模体中进行中心轴深度剂量测量。等剂量分布也通过计算机治疗计划系统,利用对已植入硅胶、丙烯酸和羟基磷灰石眼部植入物的聚苯乙烯模体进行的计算机断层扫描(CT)来计算。

结果

电子束剂量分布在测量数据和计算数据上均显示出畸变。这种效应在羟基磷灰石植入物中最为明显,对于6兆伏光子束,其透过眼部植入物的透射率约为93%,对于6兆伏电子束为60%,对于12兆伏电子束为90%。

结论

我们研究了嵌入聚苯乙烯模体中的各种材料的眼部植入物对6兆伏光子束以及6、9和12兆伏电子束剂量分布的影响。我们的研究表明,虽然6兆伏光子仅经历百分之几的衰减,但透射率为60%的较低能量电子束并非治疗眼部植入物后方肿瘤的合适选择。

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