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1
Interruption of the ferredoxin (flavodoxin) NADP+ oxidoreductase gene of Escherichia coli does not affect anaerobic growth but increases sensitivity to paraquat.大肠杆菌铁氧化还原蛋白（黄素氧还蛋白）NADP +氧化还原酶基因的中断不影响厌氧生长，但增加了对百草枯的敏感性。
J Bacteriol. 1995 Aug;177(15):4528-31. doi: 10.1128/jb.177.15.4528-4531.1995.
2
Escherichia coli ferredoxin NADP+ reductase: activation of E. coli anaerobic ribonucleotide reduction, cloning of the gene (fpr), and overexpression of the protein.大肠杆菌铁氧化还原蛋白NADP+还原酶：大肠杆菌厌氧核糖核苷酸还原的激活、基因（fpr）的克隆及该蛋白的过表达
J Bacteriol. 1993 Mar;175(6):1590-5. doi: 10.1128/jb.175.6.1590-1595.1993.
3
Flavodoxin is required for the activation of the anaerobic ribonucleotide reductase.黄素氧还蛋白是厌氧核糖核苷酸还原酶激活所必需的。
Biochem Biophys Res Commun. 1993 Dec 15;197(2):792-7. doi: 10.1006/bbrc.1993.2548.
4
The three-dimensional structure of flavodoxin reductase from Escherichia coli at 1.7 A resolution.大肠杆菌黄素氧还蛋白还原酶的三维结构，分辨率为1.7埃。
J Mol Biol. 1997 Apr 25;268(1):147-57. doi: 10.1006/jmbi.1997.0957.
5
The role of ferredoxin-NADP+ reductase in the concerted cell defense against oxidative damage -- studies using Escherichia coli mutants and cloned plant genes.铁氧化还原蛋白-NADP+还原酶在细胞协同抵御氧化损伤中的作用——利用大肠杆菌突变体和克隆的植物基因进行的研究
Eur J Biochem. 1997 Oct 15;249(2):556-63. doi: 10.1111/j.1432-1033.1997.00556.x.
6
Routes of flavodoxin and ferredoxin reduction in Escherichia coli. CoA-acylating pyruvate: flavodoxin and NADPH: flavodoxin oxidoreductases participating in the activation of pyruvate formate-lyase.大肠杆菌中黄素氧还蛋白和铁氧还蛋白的还原途径。参与丙酮酸甲酸裂解酶激活的辅酶A酰化丙酮酸：黄素氧还蛋白和NADPH：黄素氧还蛋白氧化还原酶。
Eur J Biochem. 1982 Apr;123(3):563-9.
7
Escherichia coli pyruvate:flavodoxin oxidoreductase, YdbK - regulation of expression and biological roles in protection against oxidative stress.大肠杆菌丙酮酸：黄素氧还蛋白氧化还原酶，YdbK——表达调控及其在抵抗氧化应激中的生物学作用
Genes Genet Syst. 2013;88(3):175-88. doi: 10.1266/ggs.88.175.
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NADPH: ferredoxin oxidoreductase acts as a paraquat diaphorase and is a member of the soxRS regulon.NADPH：铁氧还蛋白氧化还原酶作为百草枯双加氧酶，是soxRS调节子的成员。
Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1328-31. doi: 10.1073/pnas.91.4.1328.
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A radical-chemical route to acetyl-CoA: the anaerobically induced pyruvate formate-lyase system of Escherichia coli.通向乙酰辅酶A的自由基化学途径：大肠杆菌厌氧诱导的丙酮酸甲酸裂解酶系统
FEMS Microbiol Rev. 1990 Aug;6(4):383-98. doi: 10.1111/j.1574-6968.1990.tb04108.x.
10
Characterization of cis-acting regulatory mutations causing anaerobic expression of the sodA gene in Escherichia coli.导致大肠杆菌中sodA基因厌氧表达的顺式作用调节突变的特征分析。
Arch Biochem Biophys. 1993 May;302(2):372-9. doi: 10.1006/abbi.1993.1226.

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A new catalytic mechanism of bacterial ferredoxin-NADP reductases due to a particular NADP binding mode.由于一种特殊的 NADP 结合模式，细菌铁氧还蛋白-NADP 还原酶的新催化机制。
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2
FinR Regulates Expression of and Operons, Involved in Nicotinic Acid Degradation in Pseudomonas putida KT2440.FinR 调控 Pseudomonas putida KT2440 中参与烟酸降解的 和 操纵子的表达。
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3
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5
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6
Genome-wide mapping of TnrA-binding sites provides new insights into the TnrA regulon in Bacillus subtilis.TnrA结合位点的全基因组图谱为枯草芽孢杆菌中TnrA调控子提供了新见解。
Microbiologyopen. 2015 Jun;4(3):423-35. doi: 10.1002/mbo3.249. Epub 2015 Mar 8.
7
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of a ferredoxin/flavodoxin-NADP(H) oxidoreductase (Bc0385) from Bacillus cereus.蜡样芽孢杆菌铁氧化还原蛋白/黄素氧化还原蛋白-NADP(H)氧化还原酶（Bc0385）的克隆、表达、纯化、结晶及初步X射线衍射分析
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J Bacteriol. 2012 Mar;194(6):1552-61. doi: 10.1128/JB.06429-11. Epub 2012 Jan 6.
9
Structural-functional characterization and physiological significance of ferredoxin-NADP reductase from Xanthomonas axonopodis pv. citri.柑橘黄单胞菌 pv. 芸薹属的铁氧还蛋白-NADP 还原酶的结构-功能特征及生理意义。
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10
Comparative transcriptomic profile analysis of fed-batch cultures expressing different recombinant proteins in Escherichia coli.比较不同重组蛋白在大肠杆菌中表达的分批补料培养的转录组谱分析。
AMB Express. 2011 Oct 22;1(1):33. doi: 10.1186/2191-0855-1-33.

本文引用的文献

1
Escherichia coli ferredoxin NADP+ reductase: activation of E. coli anaerobic ribonucleotide reduction, cloning of the gene (fpr), and overexpression of the protein.大肠杆菌铁氧化还原蛋白NADP+还原酶：大肠杆菌厌氧核糖核苷酸还原的激活、基因（fpr）的克隆及该蛋白的过表达
J Bacteriol. 1993 Mar;175(6):1590-5. doi: 10.1128/jb.175.6.1590-1595.1993.
2
Molecular cloning, sequence and regulation of expression of the recA gene of the phototrophic bacterium Rhodobacter sphaeroides.光合细菌球形红杆菌recA基因的分子克隆、序列及表达调控
Mol Gen Genet. 1994 Jan;242(1):116-20. doi: 10.1007/BF00277356.
3
Flavodoxin is required for the activation of the anaerobic ribonucleotide reductase.黄素氧还蛋白是厌氧核糖核苷酸还原酶激活所必需的。
Biochem Biophys Res Commun. 1993 Dec 15;197(2):792-7. doi: 10.1006/bbrc.1993.2548.
4
NADPH: ferredoxin oxidoreductase acts as a paraquat diaphorase and is a member of the soxRS regulon.NADPH：铁氧还蛋白氧化还原酶作为百草枯双加氧酶，是soxRS调节子的成员。
Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1328-31. doi: 10.1073/pnas.91.4.1328.
5
The NADPH: sulfite reductase of Escherichia coli is a paraquat reductase.大肠杆菌的NADPH：亚硫酸盐还原酶是一种百草枯还原酶。
Eur J Biochem. 1994 Dec 1;226(2):459-63. doi: 10.1111/j.1432-1033.1994.tb20070.x.
6
Generation of the glycyl radical of the anaerobic Escherichia coli ribonucleotide reductase requires a specific activating enzyme.厌氧大肠杆菌核糖核苷酸还原酶的甘氨酰自由基的生成需要一种特定的激活酶。
J Biol Chem. 1995 Feb 10;270(6):2443-6. doi: 10.1074/jbc.270.6.2443.
7
Routes of flavodoxin and ferredoxin reduction in Escherichia coli. CoA-acylating pyruvate: flavodoxin and NADPH: flavodoxin oxidoreductases participating in the activation of pyruvate formate-lyase.大肠杆菌中黄素氧还蛋白和铁氧还蛋白的还原途径。参与丙酮酸甲酸裂解酶激活的辅酶A酰化丙酮酸：黄素氧还蛋白和NADPH：黄素氧还蛋白氧化还原酶。
Eur J Biochem. 1982 Apr;123(3):563-9.
8
Nucleotide sequence of the kanamycin resistance transposon Tn903.卡那霉素抗性转座子Tn903的核苷酸序列。
J Mol Biol. 1981 Apr 5;147(2):217-26. doi: 10.1016/0022-2836(81)90438-1.
9
Growth abnormalities in Hfr derivatives of Escherichia coli strain C.大肠杆菌C菌株的高频重组（Hfr）衍生物中的生长异常
J Gen Microbiol. 1965 Sep;40(3):365-76. doi: 10.1099/00221287-40-3-365.
10
Activation of methionine synthetase by a reduced triphosphopyridine nucleotide-dependent flavoprotein system.一种还原型三磷酸吡啶核苷酸依赖性黄素蛋白系统对蛋氨酸合成酶的激活作用。
J Biol Chem. 1974 Nov 10;249(21):6745-53.

大肠杆菌铁氧化还原蛋白（黄素氧还蛋白）NADP +氧化还原酶基因的中断不影响厌氧生长，但增加了对百草枯的敏感性。

Interruption of the ferredoxin (flavodoxin) NADP+ oxidoreductase gene of Escherichia coli does not affect anaerobic growth but increases sensitivity to paraquat.

作者信息

Bianchi V, Haggård-Ljungquist E, Pontis E, Reichard P

机构信息

Department of Genetics, Stockholm University, Sweden.

出版信息

J Bacteriol. 1995 Aug;177(15):4528-31. doi: 10.1128/jb.177.15.4528-4531.1995.

DOI:10.1128/jb.177.15.4528-4531.1995
PMID:7635836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC177208/
Abstract

Ferredoxin (flavodoxin) NADP+ oxidoreductase participates in methionine biosynthesis and in the function of two anaerobic enzymes, pyruvate formate-lyase and ribonucleotide reductase. We prepared insertion mutants of Escherichia coli lacking a functional enzyme. They do not require methionine and they grow well anaerobically, but they show increased sensitivity to paraquat.

摘要

铁氧化还原蛋白（黄素氧还蛋白）NADP⁺氧化还原酶参与甲硫氨酸的生物合成以及两种厌氧酶（丙酮酸甲酸裂解酶和核糖核苷酸还原酶）的功能。我们制备了缺乏功能性该酶的大肠杆菌插入突变体。它们不需要甲硫氨酸，并且在厌氧条件下生长良好，但对百草枯表现出更高的敏感性。