骨肉瘤和骨纤维发育不良中单个胶原链的组成及翻译后修饰
Composition and posttranslational modification of individual collagen chains from osteosarcomas and osteofibrous dysplasias.
作者信息
Lehmann H W, Wolf E, Röser K, Bodo M, Delling G, Müller P K
机构信息
Institut of Medical Molecularbiology, University of Lübeck, Germany.
出版信息
J Cancer Res Clin Oncol. 1995;121(7):413-8. doi: 10.1007/BF01212948.
Abstract
The composition of collagen was analyzed and the degree of lysyl hydroxylation of individual collagen chains was determined in four osteosarcomas and two osteofibrous dysplasias. In addition, the tumor proliferation (number of mitoses, proliferating-nuclear-antigen-positive cells, MIB) as well as the response to chemotherapy (morphological regression grade) were checked. All tumors contained a high proportion of collagen III and, in all but one osteosarcoma, pepsin-extracted collagens I and III were overmodified. Furthermore, the proportion of diglycosides in collagen I was about four times higher than in controls. The collagen composition and modification resembled those of bones at early stages of human development. One osteosarcoma and both osteofibrous dysplasias were in the normal range of lysyl hydroxylation. There was no correlation between the collagen properties and the histopathological marker of tumor proliferation.
摘要
对4例骨肉瘤和2例骨纤维发育不良进行了胶原蛋白组成分析，并测定了各条胶原蛋白链的赖氨酰羟化程度。此外，还检查了肿瘤增殖情况（有丝分裂数、增殖细胞核抗原阳性细胞、MIB）以及对化疗的反应（形态学消退分级）。所有肿瘤均含有高比例的Ⅲ型胶原蛋白，除1例骨肉瘤外，其余所有肿瘤经胃蛋白酶提取的Ⅰ型和Ⅲ型胶原蛋白均过度修饰。此外，Ⅰ型胶原蛋白中二糖苷的比例比对照组高约四倍。胶原蛋白的组成和修饰类似于人类发育早期骨骼的情况。1例骨肉瘤和2例骨纤维发育不良的赖氨酰羟化处于正常范围内。胶原蛋白特性与肿瘤增殖的组织病理学标志物之间无相关性。
相似文献
1
Composition and posttranslational modification of individual collagen chains from osteosarcomas and osteofibrous dysplasias.骨肉瘤和骨纤维发育不良中单个胶原链的组成及翻译后修饰
J Cancer Res Clin Oncol. 1995;121(7):413-8. doi: 10.1007/BF01212948.
2
Is Dissection and Preservation of Adherent Popliteal Vessels From a Posterior Soft Tissue Mass Associated With a Higher Proportion of Local Recurrence in Patients With a Distal Femoral Osteosarcoma?从后方软组织肿块中解剖和保留粘连的腘血管是否会增加股骨远端骨肉瘤患者局部复发的比例？
Clin Orthop Relat Res. 2023 Nov 1;481(11):2167-2176. doi: 10.1097/CORR.0000000000002775. Epub 2023 Aug 1.
3
Cytostatic effects in osteosarcomas as detected by flow cytometric DNA analysis after preoperative chemotherapy according to the COSS 80/82 protocol.根据COSS 80/82方案进行术前化疗后，通过流式细胞术DNA分析检测骨肉瘤中的细胞抑制作用。
J Cancer Res Clin Oncol. 1987;113(4):369-75. doi: 10.1007/BF00397721.
4
Do Patients of Different Levels of Affluence Receive Different Care for Pediatric Osteosarcomas? One Institution's Experience.不同富裕程度的患者在小儿骨肉瘤治疗上是否得到不同的护理？一家机构的经验。
Clin Orthop Relat Res. 2025 Apr 1;483(4):748-758. doi: 10.1097/CORR.0000000000003299. Epub 2024 Oct 30.
5
Composite Reconstruction With Irradiated Autograft Plus Total Hip Replacement After Type II Pelvic Resections for Tumors Is Feasible but Fraught With Complications.肿瘤Ⅱ型骨盆切除术后采用同种异体骨移植加全髋关节置换术进行复合重建是可行的，但并发症多。
Clin Orthop Relat Res. 2024 Oct 1;482(10):1825-1835. doi: 10.1097/CORR.0000000000003097. Epub 2024 Apr 26.
6
Does the Clinical Presentation of Secondary Osteosarcoma in Patients Who Survive Retinoblastoma Differ From That of Conventional Osteosarcoma and How Do We Detect Them?视网膜母细胞瘤存活患者的继发性骨肉瘤的临床表现是否与常规骨肉瘤不同，我们应如何检测？
Clin Orthop Relat Res. 2023 Nov 1;481(11):2154-2163. doi: 10.1097/CORR.0000000000002667. Epub 2023 May 5.
7
Does Augmenting Irradiated Autografts With Free Vascularized Fibula Graft in Patients With Bone Loss From a Malignant Tumor Achieve Union, Function, and Complication Rate Comparably to Patients Without Bone Loss and Augmentation When Reconstructing Intercalary Resections in the Lower Extremity?对于因恶性肿瘤导致骨缺损的患者，在重建下肢节段性切除时，采用带血管游离腓骨移植来增强照射后的自体骨移植，其骨愈合、功能及并发症发生率与无骨缺损且未进行增强的患者相比是否相当？
Clin Orthop Relat Res. 2025 Jun 26. doi: 10.1097/CORR.0000000000003599.
8
Nutritional interventions for survivors of childhood cancer.儿童癌症幸存者的营养干预措施。
Cochrane Database Syst Rev. 2016 Aug 22;2016(8):CD009678. doi: 10.1002/14651858.CD009678.pub2.
9
Sertindole for schizophrenia.用于治疗精神分裂症的舍吲哚。
Cochrane Database Syst Rev. 2005 Jul 20;2005(3):CD001715. doi: 10.1002/14651858.CD001715.pub2.
10
Does A Single Osteotomy Technique for Frozen Autograft (Pedicled Freezing) in Patients With Malignant Bone Tumors of the Long Bones Achieve Union and Local Tumor Control?对于长骨恶性骨肿瘤患者，单一截骨技术（带蒂冷冻）用于冻结自体移植物（冰冻移植）能否实现愈合和局部肿瘤控制？
Clin Orthop Relat Res. 2024 Feb 1;482(2):340-349. doi: 10.1097/CORR.0000000000002788. Epub 2023 Aug 17.
引用本文的文献
1
Identification of Regulatory Molecular "Hot Spots" for LH/PLOD Collagen Glycosyltransferase Activity.鉴定 LH/PLOD 胶原糖基转移酶活性的调控分子“热点”。
Int J Mol Sci. 2023 Jul 7;24(13):11213. doi: 10.3390/ijms241311213.
2
Comprehensive Characterization of Glycosylation and Hydroxylation of Basement Membrane Collagen IV by High-Resolution Mass Spectrometry.通过高分辨率质谱对基底膜胶原蛋白IV的糖基化和羟基化进行全面表征
J Proteome Res. 2016 Jan 4;15(1):245-58. doi: 10.1021/acs.jproteome.5b00767. Epub 2015 Dec 9.
3
Molecular Characterization of Collagen Hydroxylysine -Glycosylation by Mass Spectrometry: Current Status.通过质谱法对胶原蛋白羟赖氨酸糖基化进行分子表征：现状
Aust J Chem. 2013 Jul 18;66(7):760-769. doi: 10.1071/CH13174.
4
Mechano-regulation of collagen biosynthesis in periodontal ligament.牙周膜中胶原蛋白生物合成的机械调节
J Prosthodont Res. 2014 Oct;58(4):193-207. doi: 10.1016/j.jpor.2014.08.003. Epub 2014 Oct 11.
5
Lysine post-translational modifications of collagen.胶原蛋白的赖氨酸翻译后修饰。
Essays Biochem. 2012;52:113-33. doi: 10.1042/bse0520113.
6
Lysyl hydroxylase 3-mediated glucosylation in type I collagen: molecular loci and biological significance.赖氨酸羟化酶 3 介导的 I 型胶原糖基化：分子定位和生物学意义。
J Biol Chem. 2012 Jun 29;287(27):22998-3009. doi: 10.1074/jbc.M112.343954. Epub 2012 May 9.
7
Lysyl hydroxylase 3 glucosylates galactosylhydroxylysine residues in type I collagen in osteoblast culture.赖氨酸羟化酶 3 在成骨细胞培养物中使Ⅰ型胶原中的半乳糖基羟赖氨酸残基发生葡萄糖基化。
J Biol Chem. 2011 Mar 18;286(11):8846-56. doi: 10.1074/jbc.M110.178509. Epub 2011 Jan 10.
8
The post-translational phenotype of collagen synthesized by SAOS-2 osteosarcoma cells.SAOS-2骨肉瘤细胞合成的胶原蛋白的翻译后表型。
Bone. 2007 May;40(5):1343-51. doi: 10.1016/j.bone.2007.01.011. Epub 2007 Jan 25.
本文引用的文献
1
Biochemical and morphological modifications in rabbit Achilles tendon during maturation and ageing.兔跟腱在成熟和衰老过程中的生化及形态学改变
Biochem J. 1982 Apr 15;204(1):61-7. doi: 10.1042/bj2040061.
2
Collagen polymorphism in extracellular matrix of human osteosarcoma.人类骨肉瘤细胞外基质中的胶原蛋白多态性
J Natl Cancer Inst. 1982 Nov;69(5):1009-16.
3
Hydroxylysine glycosides: preparation and analysis by reverse phase high performance liquid chromatography.羟赖氨酸糖苷：反相高效液相色谱法的制备与分析
Ital J Biochem. 1984 Mar-Apr;33(2):117-27.
4
Morphological grades of regression in osteosarcoma after polychemotherapy - study COSS 80.骨肉瘤多药化疗后消退的形态学分级——COSS 80研究
J Cancer Res Clin Oncol. 1983;106 Suppl:21-4. doi: 10.1007/BF00625047.
5
Biologic characterization of human bone tumors. II. Distribution of different collagen types in osteosarcoma--a combined histologic, immunofluorescence and electron microscopic study.人类骨肿瘤的生物学特性。II. 骨肉瘤中不同胶原类型的分布——组织学、免疫荧光及电子显微镜联合研究
J Cancer Res Clin Oncol. 1983;106(3):234-9. doi: 10.1007/BF00402614.
6
Biochemical investigations of different forms of osteogenesis imperfecta. Evaluation of 44 cases.不同类型成骨不全症的生化研究。44例病例评估。
Connect Tissue Res. 1983;11(2-3):103-11. doi: 10.3109/03008208309004847.
7
[Cytogenesis and histogenesis of malignant and semimalignant bone tumors].[恶性及半恶性骨肿瘤的细胞发生与组织发生]
Veroff Pathol. 1984;122:1-195.
8
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
9
Assay of protocollagen lysyl hydroxylase activity in the skin of human subjects and changes in the activity with age.人类受试者皮肤中原胶原赖氨酸羟化酶活性的测定及其活性随年龄的变化。
Clin Chim Acta. 1973 Aug 30;47(2):289-94. doi: 10.1016/0009-8981(73)90326-4.
10
Osteosarcoma: pathology and classification.骨肉瘤：病理学与分类
Semin Roentgenol. 1989 Jul;24(3):143-52. doi: 10.1016/0037-198x(89)90010-2.
Zotero 插件