CA15.3、黏蛋白样癌相关抗原和癌胚抗原在确定转移性乳腺癌患者临床病程中的作用。
The usefulness of CA15.3, mucin-like carcinoma-associated antigen and carcinoembryonic antigen in determining the clinical course in patients with metastatic breast cancer.
作者信息
Deprés-Brummer P, Itzhaki M, Bakker P J, Hoek F J, Veenhof K H, de Wit R
机构信息
Laboratoire de Rythmes Biologiques et Chronotherapeutique, I.C.I.G., Hôpital Paul Brousse, France.
出版信息
J Cancer Res Clin Oncol. 1995;121(7):419-22. doi: 10.1007/BF01212949.
Levels of mucin-like carcinoma-associated antigen (MCA), CA15.3 and carcinoembryonic antigen (CEA) were measured in consecutive serum samples of 40 women with metastatic breast cancer. A change in antigen level of more than 25%, either an increase or a decrease, was considered to predict progressive or responsive disease respectively. A change of less than 25% was considered to predict stable disease. MCA, CA15.3 and CEA were elevated in the serum of 68%, 76% and 48% of the patients respectively (P < 0.05). The overall prediction of clinical course was similar for all three markers. A more than 25% increase of MCA, CA15.3, and CEA was observed in 61%, 54% and 36% respectively. The predictive value of a more than 25% increase was high for all three markers: 94%, 94%, 83%. Changes in marker levels were correlated with each other. Logistic regression analysis showed that combining MCA and CA15.3 did not improve the prediction further. In conclusion, these tumour markers may help in evaluating the disease course and there is no advantage in combining MCA and CA15.3.
在40例转移性乳腺癌女性患者的连续血清样本中检测了黏蛋白样癌相关抗原（MCA）、CA15.3和癌胚抗原（CEA）的水平。抗原水平变化超过25%，无论是升高还是降低，分别被认为可预测疾病进展或缓解。变化小于25%被认为可预测疾病稳定。分别有68%、76%和48%的患者血清中MCA、CA15.3和CEA升高（P<0.05）。对于所有三种标志物，临床病程的总体预测相似。分别有61%、54%和36%的患者观察到MCA、CA15.3和CEA升高超过25%。升高超过25%的预测价值对所有三种标志物都很高：94%、94%、83%。标志物水平变化相互关联。逻辑回归分析表明，联合MCA和CA15.3并不能进一步改善预测。总之，这些肿瘤标志物可能有助于评估疾病进程，联合MCA和CA15.3并无优势。
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