Brown S L, Salive M E, Pahor M, Foley D J, Corti M C, Langlois J A, Wallace R B, Harris T B
Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, Maryland, USA.
J Am Geriatr Soc. 1995 Aug;43(8):860-4. doi: 10.1111/j.1532-5415.1995.tb05527.x.
To evaluate the impact of caffeine in medication on sleep complaints in a community population of persons aged 67 or older.
Cross-sectional analysis.
Iowa 65+ Rural Health Study.
Those who completed their own interview, including a section on the use of medications, during the third annual in-person follow-up in 1984-1985.
trouble falling asleep or other sleep complaints. Covariates: use of caffeine-containing medication, spasmolytic, or sympathomimetic drug; number of drugs used; depressive symptoms; self-perceived health; comorbidity, hip fracture, arthritis, ulcer of stomach or intestines; and consumption of caffeinated beverages.
The prevalence of caffeinated medication use by participants was 5.4%. Those reporting the use of any caffeine-containing medication were at an increased risk of having trouble falling asleep (Odds Ratio [OR] = 1.79, 95% confidence interval [CI] = 1.19-2.68). There was no significant risk of other reported nighttime or daytime sleep problems associated with use of caffeine-containing drugs. Even after adjusting for other factors that could interfere with initiation of sleep, such as painful disease, depressive symptoms, polypharmacy, use of specific medications known to interfere with sleep, and coffee consumption, the use of caffeine-containing medication still presented a significantly increased risk of having trouble falling asleep (OR = 1.60, CI = 1.04-2.46). Although those participants using over-the-counter analgesic medication containing caffeine had an increased risk of trouble falling asleep (OR = 1.88, CI = 1.22-2.90), there was no significant risk of trouble falling asleep for those who took similar noncaffeinated OTC analgesic drugs (OR = 1.26, CI = 0.87-1.83).
The use of caffeine-containing medication is associated with sleep problems. Healthcare providers should be aware of potential problems associated with over-the-counter medications containing caffeine and should counsel patients about the potential of sleep problems. Older patients should be encouraged to read the label on medications and to select drugs that are caffeine-free when that is possible.
评估含咖啡因药物对67岁及以上社区人群睡眠问题的影响。
横断面分析。
爱荷华州65岁及以上农村健康研究。
在1984 - 1985年第三次年度面对面随访期间完成自我访谈的人，访谈内容包括用药情况。
入睡困难或其他睡眠问题。协变量：使用含咖啡因药物、解痉药或拟交感神经药；用药数量；抑郁症状；自我感知健康状况；合并症、髋部骨折、关节炎、胃或肠道溃疡；以及含咖啡因饮料的摄入量。
参与者中使用含咖啡因药物的患病率为5.4%。报告使用任何含咖啡因药物的人入睡困难的风险增加（比值比[OR]=1.79，95%置信区间[CI]=1.19 - 2.68）。使用含咖啡因药物与其他报告的夜间或白天睡眠问题无显著风险关联。即使在调整了其他可能干扰入睡的因素后，如疼痛性疾病、抑郁症状、多种药物联用、使用已知会干扰睡眠的特定药物以及咖啡摄入量，使用含咖啡因药物仍显著增加入睡困难的风险（OR = 1.60，CI = 1.04 - 2.46）。虽然使用含咖啡因的非处方镇痛药的参与者入睡困难风险增加（OR = 1.88，CI = 1.22 - 2.90），但服用类似不含咖啡因的非处方镇痛药的人入睡困难风险无显著增加（OR = 1.26，CI = 0.87 - 1.83）。
使用含咖啡因药物与睡眠问题有关。医疗保健提供者应意识到含咖啡因非处方药物的潜在问题，并应向患者咨询睡眠问题的可能性。应鼓励老年患者阅读药物标签，并尽可能选择不含咖啡因的药物。
