[牛1型腺病毒六邻体的群和型抗原特异性]

[Group and type antigenic specificity of bovine adenovirus type 1 hexons].

作者信息

Ignatov G, Khristova V

出版信息

Vet Med Nauki. 1977;14(10):97-103.

Abstract

Hexones were obtained from the bovine serotypes 1 and 3. They were investigated through the complement-fixation test along with intact virions in the presence of a hemotype and a heterotype antiserum. It was shown that the free hexones were twice as reactogenic in the homotype system as compared to the heterotype one. The hexones were found to possess two antigenic determinants--a typespecific one and a group-specific one. The latter proved sensitive to chymotrypsin. Intact vicions reacted chiefly type-specifically. Discussed is the problem of the space disposition of the type -and group-specific antigen determinants of the hexones in sito in the virions.

摘要

己糖醛酸从牛血清型1和3中获得。在存在血型和异型抗血清的情况下，通过补体结合试验将它们与完整病毒粒子一起进行研究。结果表明，在同型系统中，游离己糖醛酸的反应原性是异型系统中的两倍。已发现己糖醛酸具有两个抗原决定簇——一个型特异性决定簇和一个群特异性决定簇。后者被证明对胰凝乳蛋白酶敏感。完整病毒粒子主要进行型特异性反应。文中讨论了病毒粒子中己糖醛酸的型特异性和群特异性抗原决定簇在原位的空间排列问题。