蛋白质磷酸化的抑制作用可调节Jak家族蛋白酪氨酸激酶的表达。
Inhibition of protein phosphorylation modulates expression of the Jak family protein tyrosine kinases.
作者信息
Fiorucci G, Percario Z A, Marcolin C, Coccia E M, Affabris E, Romeo G
机构信息
Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy.
出版信息
J Virol. 1995 Sep;69(9):5833-7. doi: 10.1128/JVI.69.9.5833-5837.1995.
Abstract
Treatment of murine Friend cells with a dose of the protein kinase inhibitor staurosporine, which is able to block the response of the cells to interferons, appears to inhibit phosphorylation of Jak proteins and, interestingly, to specifically reduce tyk2 and Jak1 expression and to increase Jak2 both in the presence and in the absence of interferons. Therefore, a potential role for phosphorylation events in the regulation of expression of the Jak family members is suggested.
摘要
用一定剂量的蛋白激酶抑制剂星形孢菌素处理小鼠Friend细胞，该抑制剂能够阻断细胞对干扰素的反应，这似乎会抑制Jak蛋白的磷酸化，有趣的是，无论有无干扰素存在，它都会特异性降低tyk2和Jak1的表达，并增加Jak2的表达。因此，提示了磷酸化事件在Jak家族成员表达调控中的潜在作用。
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