Sadowski H B, Shuai K, Darnell J E, Gilman M Z
Cold Spring Harbor Laboratory, NY 11724.
Science. 1993 Sep 24;261(5129):1739-44. doi: 10.1126/science.8397445.
Growth factors and cytokines act through cell surface receptors with different biochemical properties. Yet each type of receptor can elicit similar as well as distinct biological responses in target cells, suggesting that distinct classes of receptors activate common gene sets. Epidermal growth factor, interferon-gamma, and interleukin-6 all activated, through direct tyrosine phosphorylation, latent cytoplasmic transcription factors that recognized similar DNA elements. However, different ligands activated different patterns of factors with distinct DNA-binding specificities in the same and different cells. Thus, unrelated receptors may activate a common nuclear signal transduction pathway that, through differential use of latent cytoplasmic proteins, permits these receptors to regulate both common and unique sets of genes.
生长因子和细胞因子通过具有不同生化特性的细胞表面受体发挥作用。然而，每种类型的受体都能在靶细胞中引发相似以及不同的生物学反应，这表明不同类别的受体激活共同的基因集。表皮生长因子、γ干扰素和白细胞介素-6均通过直接酪氨酸磷酸化激活了识别相似DNA元件的潜在细胞质转录因子。然而，不同的配体在相同和不同的细胞中激活具有不同DNA结合特异性的不同因子模式。因此，不相关的受体可能激活共同的核信号转导途径，该途径通过对潜在细胞质蛋白的差异利用，使这些受体能够调节共同和独特的基因集。
