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1
Sequences within the parvovirus minute virus of mice NS2-specific exon are required for inclusion of this exon into spliced steady-state RNA.小鼠细小病毒NS2特异性外显子中的序列是该外显子被包含在剪接的稳态RNA中的必要条件。
J Virol. 1995 Sep;69(9):5864-8. doi: 10.1128/JVI.69.9.5864-5868.1995.
2
CA- and purine-rich elements form a novel bipartite exon enhancer which governs inclusion of the minute virus of mice NS2-specific exon in both singly and doubly spliced mRNAs.富含CA和嘌呤的元件形成一种新型的双组分外显子增强子，其在单剪接和双剪接的mRNA中均调控小鼠微小病毒NS2特异性外显子的包含。
Mol Cell Biol. 1999 Jan;19(1):364-75. doi: 10.1128/MCB.19.1.364.
3
Inclusion of the NS2-specific exon in minute virus of mice mRNA is facilitated by an intronic splicing enhancer that affects definition of the downstream small intron.小鼠微小病毒mRNA中NS2特异性外显子的包含受到一个内含子剪接增强子的促进，该增强子影响下游小内含子的界定。
Virology. 1999 May 25;258(1):84-94. doi: 10.1006/viro.1999.9696.
4
A premature termination codon interferes with the nuclear function of an exon splicing enhancer in an open reading frame-dependent manner.一个提前终止密码子以开放阅读框依赖的方式干扰外显子剪接增强子的核功能。
Mol Cell Biol. 1999 Mar;19(3):1640-50. doi: 10.1128/MCB.19.3.1640.
5
Efficient excision of the upstream large intron from P4-generated pre-mRNA of the parvovirus minute virus of mice requires at least one donor and the 3' splice site of the small downstream intron.从小鼠细小病毒P4产生的前体mRNA中高效切除上游大内含子，至少需要一个供体位点和小的下游内含子的3'剪接位点。
J Virol. 1995 Oct;69(10):6170-9. doi: 10.1128/JVI.69.10.6170-6179.1995.
6
Alternative splicing of pre-mRNAs encoding the nonstructural proteins of minute virus of mice is facilitated by sequences within the downstream intron.编码小鼠微小病毒非结构蛋白的前体mRNA的可变剪接由下游内含子中的序列促进。
J Virol. 1994 May;68(5):2849-59. doi: 10.1128/JVI.68.5.2849-2859.1994.
7
A premature termination codon in either exon of minute virus of mice P4 promoter-generated pre-mRNA can inhibit nuclear splicing of the intervening intron in an open reading frame-dependent manner.小鼠微小病毒P4启动子产生的前体mRNA的任一外显子中的提前终止密码子可通过开放阅读框依赖性方式抑制中间内含子的核剪接。
J Biol Chem. 1999 Aug 6;274(32):22452-8. doi: 10.1074/jbc.274.32.22452.
8
Intron definition is required for excision of the minute virus of mice small intron and definition of the upstream exon.小鼠微小病毒小内含子的切除及上游外显子的界定需要内含子界定。
J Virol. 1998 Mar;72(3):1834-43. doi: 10.1128/JVI.72.3.1834-1843.1998.
9
Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product.当无义突变中断最终剪接产物任一外显子的阅读框时，它们会顺式抑制微小病毒M RNA的剪接。
Genes Dev. 1992 Jun;6(6):1107-19. doi: 10.1101/gad.6.6.1107.
10
Modulation of in vitro splicing of the upstream intron by modifying an intra-exon sequence which is deleted from the dystrophin gene in dystrophin Kobe.通过修饰肌营养不良蛋白神户型中从肌营养不良蛋白基因中缺失的外显子内序列来调节上游内含子的体外剪接。
J Clin Invest. 1995 Feb;95(2):515-20. doi: 10.1172/JCI117693.

引用本文的文献

1
Binding of CCCTC-Binding Factor (CTCF) to the Minute Virus of Mice Genome Is Important for Proper Processing of Viral P4-Generated Pre-mRNAs.CCCTC 结合因子（CTCF）与小鼠微小病毒基因组的结合对于病毒 P4 生成的前体 mRNA 的正确加工很重要。
Viruses. 2020 Nov 30;12(12):1368. doi: 10.3390/v12121368.
2
Splicing of the large intron present in the nonstructural gene of minute virus of mice is governed by TIA-1/TIAR binding downstream of the nonconsensus donor.小鼠微小病毒非结构基因中存在的大内含子的剪接受位于非共识供体下游的TIA-1/TIAR结合调控。
J Virol. 2009 Jun;83(12):6306-11. doi: 10.1128/JVI.00213-09. Epub 2009 Apr 1.
3
A premature termination codon interferes with the nuclear function of an exon splicing enhancer in an open reading frame-dependent manner.一个提前终止密码子以开放阅读框依赖的方式干扰外显子剪接增强子的核功能。
Mol Cell Biol. 1999 Mar;19(3):1640-50. doi: 10.1128/MCB.19.3.1640.
4
CA- and purine-rich elements form a novel bipartite exon enhancer which governs inclusion of the minute virus of mice NS2-specific exon in both singly and doubly spliced mRNAs.富含CA和嘌呤的元件形成一种新型的双组分外显子增强子，其在单剪接和双剪接的mRNA中均调控小鼠微小病毒NS2特异性外显子的包含。
Mol Cell Biol. 1999 Jan;19(1):364-75. doi: 10.1128/MCB.19.1.364.
5
Intron definition is required for excision of the minute virus of mice small intron and definition of the upstream exon.小鼠微小病毒小内含子的切除及上游外显子的界定需要内含子界定。
J Virol. 1998 Mar;72(3):1834-43. doi: 10.1128/JVI.72.3.1834-1843.1998.
6
Efficient excision of the upstream large intron from P4-generated pre-mRNA of the parvovirus minute virus of mice requires at least one donor and the 3' splice site of the small downstream intron.从小鼠细小病毒P4产生的前体mRNA中高效切除上游大内含子，至少需要一个供体位点和小的下游内含子的3'剪接位点。
J Virol. 1995 Oct;69(10):6170-9. doi: 10.1128/JVI.69.10.6170-6179.1995.

本文引用的文献

1
The role of exon sequences in splice site selection.外显子序列在剪接位点选择中的作用。
Genes Dev. 1993 Mar;7(3):407-18. doi: 10.1101/gad.7.3.407.
2
The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element.心肌肌钙蛋白T可变外显子包含一个新的富含嘌呤的正性剪接元件。
Mol Cell Biol. 1993 Jun;13(6):3660-74. doi: 10.1128/mcb.13.6.3660-3674.1993.
3
Genomic organization and mapping of transcription and translation products of the NADL-2 strain of porcine parvovirus.猪细小病毒NADL-2株的基因组组织及转录和翻译产物的定位
Virology. 1993 Nov;197(1):86-98. doi: 10.1006/viro.1993.1569.
4
Alternative splicing of pre-mRNAs encoding the nonstructural proteins of minute virus of mice is facilitated by sequences within the downstream intron.编码小鼠微小病毒非结构蛋白的前体mRNA的可变剪接由下游内含子中的序列促进。
J Virol. 1994 May;68(5):2849-59. doi: 10.1128/JVI.68.5.2849-2859.1994.
5
The genome of minute virus of mice, an autonomous parvovirus, encodes two overlapping transcription units.小鼠微小病毒（一种自主细小病毒）的基因组编码两个重叠的转录单元。
Nucleic Acids Res. 1983 Feb 25;11(4):1019-38. doi: 10.1093/nar/11.4.1019.
6
The minute virus of mice P39 transcription unit can encode both capsid proteins.小鼠微小病毒P39转录单元可编码两种衣壳蛋白。
J Virol. 1986 Mar;57(3):1163-7. doi: 10.1128/JVI.57.3.1163-1167.1986.
7
Three splicing patterns are used to excise the small intron common to all minute virus of mice RNAs.三种剪接模式用于切除所有小鼠微小病毒RNA共有的小内含子。
J Virol. 1986 Dec;60(3):1170-4. doi: 10.1128/JVI.60.3.1170-1174.1986.
8
Minute virus of mice (MVM) mRNAs predominantly polyadenylate at a single site.小鼠微小病毒（MVM）的信使核糖核酸（mRNA）主要在单个位点进行多聚腺苷酸化。
Virology. 1987 Oct;160(2):511-4. doi: 10.1016/0042-6822(87)90028-6.
9
DNA sequence of the lymphotropic variant of minute virus of mice, MVM(i), and comparison with the DNA sequence of the fibrotropic prototype strain.小鼠微小病毒嗜淋巴细胞变异株（MVM(i)）的DNA序列及其与嗜纤维原型株DNA序列的比较。
J Virol. 1986 Feb;57(2):656-69. doi: 10.1128/JVI.57.2.656-669.1986.
10
The autonomously replicating parvoviruses of vertebrates.脊椎动物的自主复制细小病毒
Adv Virus Res. 1987;33:91-174. doi: 10.1016/s0065-3527(08)60317-6.

小鼠细小病毒NS2特异性外显子中的序列是该外显子被包含在剪接的稳态RNA中的必要条件。

Sequences within the parvovirus minute virus of mice NS2-specific exon are required for inclusion of this exon into spliced steady-state RNA.

作者信息

Zhao Q, Mathur S, Burger L R, Pintel D J

机构信息

Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia 65212, USA.

出版信息

J Virol. 1995 Sep;69(9):5864-8. doi: 10.1128/JVI.69.9.5864-5868.1995.

DOI:10.1128/JVI.69.9.5864-5868.1995
PMID:7637034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189462/
Abstract

When the minute virus of mice NS2-specific exon was modified by either substitution or deletion, most P4-generated pre-mRNA was spliced from the large-intron donor at nucleotide 514 to the small-intron acceptor at nucleotide 2377. Improvement to consensus of large-intron splice sites in such mutants did not suppress exon skipping or restore large-intron excision. Therefore, sequences within the NS2-specific exon are required for inclusion of this exon into spliced, steady-state minute virus of mice RNA.

摘要

当小鼠微小病毒NS2特异性外显子通过替换或缺失进行修饰时，大多数由P4产生的前体mRNA从核苷酸514处的大内含子供体剪接到核苷酸2377处的小内含子受体。此类突变体中大内含子剪接位点的一致性改善并未抑制外显子跳跃或恢复大内含子切除。因此，NS2特异性外显子内的序列是该外显子包含在剪接的、稳定状态的小鼠微小病毒RNA中的必需条件。