Tai M, Demachi K, Simizu Y
Research Laboratories, Toyama Chemical Co., Ltd.
Jpn J Antibiot. 1995 May;48(5):656-64.
The metabolism of T-3761 in mouse, rat, rabbit, dog and monkey was studied. Four metabolites, other than unchanged T-3761, were detected and identified as follows: T-3761 glucuronide; T-3761M1, adduct of glucose; T-3761M2 and T-3761M3, compounds metabolized at 1-aminocyclopropyl ring. In urine of mouse, T-3761 glucuronide was mainly detected, but in urine of other animals, T-3761 was mainly detected.
研究了T-3761在小鼠、大鼠、兔子、狗和猴子体内的代谢情况。除未变化的T-3761外，还检测并鉴定出四种代谢产物，具体如下：T-3761葡糖醛酸苷；T-3761M1，葡萄糖加合物；T-3761M2和T-3761M3，在1-氨基环丙基环处代谢的化合物。在小鼠尿液中，主要检测到T-3761葡糖醛酸苷，但在其他动物尿液中，主要检测到T-3761。
