Hayakawa H, Hayashi K, Nakafuku K, Takano Y, Takagi H, Nakajima Y
Research Laboratories, Toyama Chemical Co., Ltd.
Jpn J Antibiot. 1995 May;48(5):686-91.
Placental transfer and mammary excretion of radioactivity were investigated in the pregnant rats on day 19 of pregnancy, in the pregnant mice on day 18 of pregnancy, and in the lactating rats after oral administration of 5 mg/kg of [14C] T-3761. 1. Transfer of radioactivity to fetus was observed in rats and mice and the concentration in fetus was 0.2-0.5 times higher than the maternal plasma. 2. The radioactivity was excreted into the milk and the concentration in milk was higher than those of blood levels (milk/blood = 1.3-5.8). The radioactivity in milk declined more slowly than in blood.
在妊娠第19天的孕鼠、妊娠第18天的孕鼠以及口服5mg/kg [14C] T - 3761后的泌乳大鼠中，研究了放射性物质的胎盘转运和乳腺排泄情况。1. 在大鼠和小鼠中均观察到放射性物质向胎儿的转运，胎儿体内的浓度比母体血浆高0.2 - 0.5倍。2. 放射性物质排泄到乳汁中，乳汁中的浓度高于血液水平（乳汁/血液 = 1.3 - 5.8）。乳汁中的放射性物质下降速度比血液中的慢。
