Kobayashi S, Inoue A
Jpn J Antibiot. 1985 Apr;38(4):1102-6.
The placental transfer and transition into milk of bacmecillinam (KW-1100), a new semisynthetic penicillin, have been studied with 14C-KW-1100 administered orally in the pregnant and lactating rats, respectively. The level of 14C-KW-1100 in the umbilical cord blood was 7.2% of the peak maternal blood level and the radioactivity was eliminated slowly. At the peak fetus level (4 hours after administration), the radioactivity transferred into the fetuses was found to be 0.01% of the dose. 14C-KW-1100 was distributed into the uterus, ovary, placenta and consistently into the fetal membrane. 14C-KW-1100 was excreted into milk slightly, and the concentration of radioactivity in milk did not exceed the maternal peak blood level.
已分别在怀孕和哺乳的大鼠中口服给予14C标记的新型半合成青霉素bacmecillinam（KW - 1100），研究了其胎盘转运及向乳汁中的转移情况。脐血中14C - KW - 1100的水平为母体血药峰浓度的7.2%，放射性消除缓慢。在胎儿水平峰值（给药后4小时），发现转移至胎儿体内的放射性为剂量的0.01%。14C - KW - 1100分布于子宫、卵巢、胎盘，并始终存在于胎膜中。14C - KW - 1100少量排泄到乳汁中，乳汁中的放射性浓度未超过母体血药峰浓度。
